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首页> 外文期刊>Diabetes >Overfeeding Polyunsaturated and Saturated Fat Causes Distinct Effects on Liver and Visceral Fat Accumulation in Humans
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Overfeeding Polyunsaturated and Saturated Fat Causes Distinct Effects on Liver and Visceral Fat Accumulation in Humans

机译：过量摄入多不饱和和饱和脂肪对人类肝脏和内脏脂肪积累产生明显影响

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摘要

Excess ectopic fat storage is linked to type 2 diabetes. The importance of dietary fat composition for ectopic fat storage in humans is unknown. We investigated liver fat accumulation and body composition during overfeeding saturated fatty acids (SFAs) or polyunsaturated fatty acids (PUFAs). LIPOGAIN was a double-blind, parallel-group, randomized trial. Thirty-nine young and normal-weight individuals were overfed muffins high in SFAs (palm oil) or n-6 PUFAs (sunflower oil) for 7 weeks. Liver fat, visceral adipose tissue (VAT), abdominal subcutaneous adipose tissue (SAT), total adipose tissue, pancreatic fat, and lean tissue were assessed by magnetic resonance imaging. Transcriptomics were performed in SAT. Both groups gained similar weight. SFAs, however, markedly increased liver fat compared with PUFAs and caused a twofold larger increase in VAT than PUFAs. Conversely, PUFAs caused a nearly threefold larger increase in lean tissue than SFAs. Increase in liver fat directly correlated with changes in plasma SFAs and inversely with PUFAs. Genes involved in regulating energy dissipation, insulin resistance, body composition, and fat-cell differentiation in SAT were differentially regulated between diets, and associated with increased PUFAs in SAT. In conclusion, overeating SFAs promotes hepatic and visceral fat storage, whereas excess energy from PUFAs may instead promote lean tissue in healthy humans.
机译：异位脂肪过多与2型糖尿病有关。饮食中脂肪组成对于人类异位脂肪存储的重要性尚不明确。我们调查了过量摄入饱和脂肪酸（SFA）或多不饱和脂肪酸（PUFA）期间肝脏脂肪的积累和身体成分。 LIPOGAIN是一项双盲，平行组，随机试验。对39名年轻和体重正常的人喂食高SFA（棕榈油）或n-6 PUFA（向日葵油）高的松饼，持续7周。通过磁共振成像评估肝脂肪，内脏脂肪组织（VAT），腹部皮下脂肪组织（SAT），总脂肪组织，胰腺脂肪和瘦肉组织。转录组学在SAT中进行。两组的体重相似。然而，与PUFA相比，SFA显着增加了肝脏脂肪，并且导致增值税的增加是PUFA的两倍。相反，PUFA引起的瘦组织增加量几乎是SFA的三倍。肝脂肪的增加与血浆SFA的变化直接相关，而与PUFA则相反。饮食中涉及调节能量耗散，胰岛素抵抗，身体组成和脂肪细胞分化的基因在饮食之间存在差异性调节，并且与SAT中PUFA的增加有关。总之，暴饮暴食的SFA会促进肝脏和内脏脂肪的储存，而PUFA的多余能量可能会促进健康人的瘦肉组织。

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  • 来源
    《Diabetes》 |2014年第7期|2356-2368|共13页
  • 作者

    Fredrik Rosqvist; David Iggman; Joel Kullberg; Jonathan Cedernaes; Hans-Erik Johansson; Anders Larsson; Lars Johansson; Hakan Ahlstroem; Peter Arner; Ingrid Dahlman; Ulf Riserus;

  • 作者单位

    Clinical Nutrition and Metabolism, Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden;

    Clinical Nutrition and Metabolism, Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden,Center for Clinical Research Dalarna, Falun, Sweden;

    Department of Radiology, Uppsala University, Uppsala, Sweden;

    Department of Neuroscience, Uppsala University, Uppsala Biomedical Center,Uppsala, Sweden;

    Clinical Nutrition and Metabolism, Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden;

    Department of Medical Sciences, Uppsala University, Uppsala, Sweden;

    Department of Radiology, Uppsala University, Uppsala, Sweden,Research and Development, AstraZeneca, Molndal, Sweden;

    Department of Radiology, Uppsala University, Uppsala, Sweden;

    Department of Medicine, Karolinska Institutet, Karolinska University Hospital,Huddinge, Stockholm, Sweden;

    Department of Medicine, Karolinska Institutet, Karolinska University Hospital,Huddinge, Stockholm, Sweden;

    Clinical Nutrition and Metabolism, Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden;

  • 收录信息 美国《科学引文索引》(SCI);美国《化学文摘》(CA);
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