Multipotential nestin-positive stem cells isolated from adult pancreatic islets differentiate ex vivo into pancreatic endocrin, exocrine, and hepatic phenotypes

Henryk Zulewski; Elizabeth J.Abraham; Meissa J.Gerlach

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Multipotential nestin-positive stem cells isolated from adult pancreatic islets differentiate ex vivo into pancreatic endocrin, exocrine, and hepatic phenotypes

机译：从成年胰岛分离的多潜能巢蛋白阳性干细胞离体分化成胰腺内分泌，外分泌和肝表型

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The ehdocrine cells of the rat pancreatic islets of Lang- erhans, including insulin-producingβ-cells, turn over every 40-50 days by processes of apoptosis and the proliferation and differentiation of new islet cells(neo- genesis)from progenitor epithelia cells located in the pancreatic ducts. However, the administration to rats of islet trophic factors such as glucose or glucagon-like peptide 1 for 48 h results in a doubling of islet cell mass, suggesting that islet progenitor cells may reside within the islets themselves.

机译：大鼠郎格罕氏胰岛的内分泌细胞，包括产生胰岛素的β细胞，每40-50天通过凋亡过程以及来自祖先上皮细胞的新胰岛细胞（新生）的增殖和分化过程而翻转在胰管中。但是，向大鼠施用48小时的胰岛营养因子（例如葡萄糖或胰高血糖素样肽1）会导致胰岛细胞量增加一倍，这表明胰岛祖细胞可能驻留在胰岛自身中。

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《Diabetes》 |2001年第3期|p.521-533|共13页
作者
Henryk Zulewski; Elizabeth J.Abraham; Meissa J.Gerlach;
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收录信息美国《科学引文索引》(SCI);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类内分泌腺疾病及代谢病;泌尿科学（泌尿生殖系疾病）;
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1. Coexpression of Pdx1 and betacellulin in mesenchymal stem cells could promote the differentiation of nestin-positive epithelium-like progenitors and pancreatic islet-like spheroids. [J] . Li L, Li F, Qi H, Stem cells and development . 2008,第4期

机译：Pdx1和βcellulin在间充质干细胞中的共表达可以促进巢蛋白阳性上皮样祖细胞和胰岛样球体的分化。
2. Multipotential nestin and Isl-1 positive mesenchymal stem cells isolated from human pancreatic islets [J] . Eberhardt M, Salmon P, von Mach MA, Biochemical and Biophysical Research Communications . 2006,第3期

机译：从人胰岛分离的多能巢蛋白和Isl-1阳性间充质干细胞
3. Differentiation of Mesenchymal Stem Cells towards an insulin-releasing phenotype after co-culture with Pancreatic Islets [J] . Arianna Scuteri, Elisabetta Donzelli, Virginia Rodriguez-Menendez, Italian Journal of Anatomy and Embryology . 2012,第2期

机译：与胰岛共培养后，间充质干细胞向胰岛素释放表型的分化
4. Leucine improved the pancreatic exocrine function in vivo and in vitro [C] . Kai Liu 4th international symposium on dairy cow nutrition and milk quality proceedings . 2015

机译：亮氨酸改善体内和体外的胰腺外分泌功能
5. NK cells lyse poorly differentiated but not well-differentiated pancreatic cancer cells; role of NK cells in selection and differentiation of pancreatic cancer stem cells. [D] . Maung, Phyu Ou. 2014

机译：NK细胞裂解分化差但分化差的胰腺癌细胞；细胞在胰腺癌干细胞选择和分化中的作用
6. Differentiation of Mesenchymal Stem Cells Derived from Pancreatic Islets and Bone Marrow into Islet-Like Cell Phenotype [O] . Cristina Zanini, Stefania Bruno, Giorgia Mandili, 2011

机译：从胰岛和骨髓衍生的成胰岛样细胞表型间质干细胞的分化
7. Multipotential nestin-positive stem cells isolated from adult pancreatic islets differentiate ex vivo into pancreatic endocrine, exocrine, and hepatic phenotypes [O] . Zulewski Henryk, Vallejo Mario 2013

机译：从成年胰岛分离的多潜能巢蛋白阳性干细胞离体分化成胰腺内分泌，外分泌和肝表型

Multipotential nestin-positive stem cells isolated from adult pancreatic islets differentiate ex vivo into pancreatic endocrin, exocrine, and hepatic phenotypes

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