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首页> 外文期刊>Diabetes >Brief Genetics Report: Genetic Analysis of Chromosome 2 in Type 1 Diabetes: Analysis of Putative Loci IDDM7, IDDM12, an IDDM13 And Candidate Genes NRAMP2 and IA-2 and the Interleukin-1 Gene Cluster
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Brief Genetics Report: Genetic Analysis of Chromosome 2 in Type 1 Diabetes: Analysis of Putative Loci IDDM7, IDDM12, an IDDM13 And Candidate Genes NRAMP2 and IA-2 and the Interleukin-1 Gene Cluster

机译:简要的遗传学报告:1型糖尿病2号染色体的遗传分析:推定基因座IDDM7,IDDM12,IDDM13和候选基因NRAMP2和IA-2和白介素-1基因簇的分析

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摘要

In the spontaneous moue model of type 1 diabetes, the nonobese (NOD) strain, a type 1 diabetes locus, Idd5, has been mapped to chromosome 1 (1). Because mouse chromosome 1 shares a homolo- Gous 33-cM region between the genes col3a1 and col6a3 With human chromosome 2q31-q35 (data shown at http://www.ncbi.nlm.nih.gov/Omim/homology/), several groups have searched chromosome 2 for loci affecting human type 1 diabetes. Previous studies have provided evi- dence for at least three type 1 diabetes loci (IDDM7, IDDM12, and IDDM13) with a 23cM region of chromosome 2q31-q35 (2-5).
机译:在1型糖尿病的自发性情绪模型中,非肥胖(NOD)菌株(1型糖尿病的基因座Idd5)已被定位到1号染色体(1)。由于小鼠1号染色体与人类2q31-q35染色体之间的基因col3a1和col6a3之间共享一个同源的33-cM区(数据显示在http://www.ncbi.nlm.nih.gov/Omim/homology/),他们已经在2号染色体上搜索了影响人类1型糖尿病的基因座。先前的研究已经提供了至少3个1型糖尿病基因座(IDDM7,IDDM12和IDDM13)的证据,其染色体2q31-q35的23cM区(2-5)。

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