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首页> 外文期刊>Acta Diabetologica >Characterization of beta cell and incretin function in patients with MODY1 (HNF4A MODY) and MODY3 (HNF1A MODY) in a Swedish patient collection
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Characterization of beta cell and incretin function in patients with MODY1 (HNF4A MODY) and MODY3 (HNF1A MODY) in a Swedish patient collection

机译：瑞典患者样本中MODY1（HNF4A MODY）和MODY3（HNF1A MODY）患者的β细胞和肠降血糖素功能的特征

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摘要

The aim of this study was to evaluate the beta cell and incretin function in patients with HNF4A and HNF1A MODY during a test meal. Clinical characteristics and biochemical data (glucose, proinsulin, insulin, C-peptide, GLP-1 and GIP) during a test meal were compared between MODY patients from eight different families. BMI-matched T2D and healthy subjects were used as two separate control groups. The early phase of insulin secretion was attenuated in HNF4A, HNF1A MODY and T2D (AUC0-30 controls: 558.2 ± 101.2, HNF4A MODY: 93.8 ± 57.0, HNF1A MODY: 170.2 ± 64.5, T2D: 211.2 ± 65.3, P 0.01). Markedly reduced levels of proinsulin were found in HNF4A MODY compared to T2D and that tended to be so also in HNF1A MODY (HNF4A MODY: 3.7 ± 1.2, HNF1A MODY: 8.3 ± 3.8 vs. T2D: 26.6 ± 14.3). Patients with HNF4A MODY had similar total GLP-1 and GIP responses as controls (GLP-1 AUC: (control: 823.9 ± 703.8, T2D: 556.4 ± 698.2, HNF4A MODY: 1,257.0 ± 999.3, HNF1A MODY: 697.1 ± 818.4) but with a different secretion pattern. The AUC insulin during the test meal was strongly correlated with the GIP secretion (Correlation coefficient 1.0, P 0.001). No such correlation was seen for insulin and GLP-1. Patients with HNF4A and HNF1A MODY showed an attenuated early phase of insulin secretion similar to T2Ds. AUC insulin during the test meal was strongly correlated with GIP secretion, whereas no such correlation was seen for insulin and GLP-1. Thus, GIP may be a more important factor for insulin secretion than GLP-1 in MODY patients.
机译：这项研究的目的是评估测试餐期间HNF4A和HNF1A MODY患者的β细胞和肠降血糖素功能。比较了来自八个不同家庭的MODY患者在测试餐期间的临床特征和生化数据（葡萄糖，胰岛素原，胰岛素，C肽，GLP-1和GIP）。将BMI匹配的T2D和健康受试者作为两个独立的对照组。在HNF4A，HNF1A MODY和T2D中，胰岛素分泌的早期阶段减弱（AUC0-30对照：558.2±101.2，HNF4A MODY：93.8±57.0，HNF1A MODY：170.2±64.5，T2D：211.2±65.3，P <0.01）。与T2D相比，HNF4A MODY中的胰岛素原水平显着降低，在HNF1A MODY中也是如此（HNF4A MODY：3.7±1.2，HNF1A MODY：8.3±3.8 vs.T2D：26.6±14.3）。 HNF4A MODY患者的总GLP-1和GIP反应与对照组相似（GLP-1 AUC：（对照组：823.9±703.8，T2D：556.4±698.2，HNF4A MODY：1,257.0±999.3，HNF1A MODY：697.1±818.4）试验膳食中的AUC胰岛素与GIP分泌密切相关（相关系数1.0，P <0.001），胰岛素和GLP-1均无此相关性，HNF4A和HNF1A MODY患者显示减弱胰岛素分泌的早期阶段类似于T2Ds。试验餐中的AUC胰岛素与GIP分泌密切相关，而对胰岛素和GLP-1则没有这种相关性，因此，GIP可能比GLP- MODY患者中为1。

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  • 来源
    《Acta Diabetologica》 |2012年第5期|p.349-354|共6页
  • 作者

    E. Ekholm; N. Shaat; J. J. Holst;

  • 作者单位

    Department of Clinical Sciences/Diabetes and Endocrinology, Malmö University Hospital, Lund University, Malmö, Sweden;

    Department of Clinical Sciences/Diabetes and Endocrinology, Malmö University Hospital, Lund University, Malmö, Sweden;

    Department of Medical Physiology, University of Copenhagen, Copenhagen, Denmark;

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  • 关键词

    Diabetes mellitus; MODY diabetes mellitus; Gene;

    机译：糖尿病;MODY糖尿病;基因;

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