Four weeks of near-normalisation of blood glucose improves the insulin response to glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide in patients with type 2 diabetes

P. V. Højberg; T. Vilsbøll; R. Rabøl; F. K. Knop; M. Bache; T. Krarup; J. J. Holst; S. Madsbad

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Four weeks of near-normalisation of blood glucose improves the insulin response to glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide in patients with type 2 diabetes

机译：血糖近乎正常化的四个星期改善了2型糖尿病患者对胰高血糖素样肽1和葡萄糖依赖性促胰岛素多肽的胰岛素反应

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Objective The incretin effect is attenuated in patients with type 2 diabetes mellitus, partly as a result of impaired beta cell responsiveness to glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1). The aim of the present study was to investigate whether 4 weeks of near-normalisation of the blood glucose level could improve insulin responses to GIP and GLP-1 in patients with type 2 diabetes.

机译：目的2型糖尿病患者的肠降血糖素作用减弱，部分原因是β细胞对葡萄糖依赖性促胰岛素多肽（GIP）和胰高血糖素样肽1（GLP-1）的反应能力减弱。本研究的目的是调查4周血糖水平近乎正常化能否改善2型糖尿病患者对GIP和GLP-1的胰岛素反应。

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《Diabetologia》 |2009年第2期|p.199-207|共9页
作者
P. V. Højberg; T. Vilsbøll; R. Rabøl; F. K. Knop; M. Bache; T. Krarup; J. J. Holst; S. Madsbad;
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正文语种 eng
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Beta; cell responsiveness; Glucose; dependent insulinotropic polypeptide; Glugagon like peptide; 1; Incretin hormones; Insulin treatment; Type 2 diabetes mellitus;

机译：Beta;细胞反应性葡萄糖;依赖的促胰岛素多肽;胰高血糖素样肽;1;Incretin激素;胰岛素治疗;2型糖尿病;

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专利

1. Effects of consumption of main and side dishes with white rice on postprandial glucose, insulin, glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 responses in healthy Japanese men. [J] . Kameyama N, Maruyama C, Matsui S, The British Journal of Nutrition . 2014,第9期

机译：食用白米饭的主菜和配菜对健康日本男性的餐后葡萄糖，胰岛素，葡萄糖依赖性促胰岛素多肽和胰高血糖素样肽1反应的影响。
2. Effects of consumption of main and side dishes with white rice on postprandial glucose, insulin, glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 responses in healthy Japanese men [J] . Chizuko Maruyama, Noriko Kameyama, Risa Araki, The British Journal of Nutrition . 2014,第9期

机译：食用白米饭的主菜和配菜对健康日本男性的餐后葡萄糖，胰岛素，葡萄糖依赖性促胰岛素多肽和胰高血糖素样肽-1反应的影响
3. Pharmacodynamics, pharmacokinetics and safety of multiple ascending doses of the novel dual glucose-dependent insulinotropic polypeptide/glucagon-like peptide-1 agonist RG7697 in people with type 2 diabetes mellitus [J] . Schmitt Christophe, Portron Agnes, Jadidi Shirin, Diabetes, obesity & metabolism . 2017,第10期

机译：药效学，药代动力学，多种上升剂量的新型双葡萄糖依赖性多肽/胰高血糖素样肽-1激动剂RG7697的糖尿病患者
4. The Fluctuation of Blood Glucose, Insulin and Glucagon Concentrations Before and After Insulin Therapy in Type 1 Diabetes [C] . Idam Arif, Zulfa Nasir International Conference on Mathematics and Natural Sciences . 2015

机译：胰岛素治疗前后血糖，胰岛素和胰高血糖素浓度在1型糖尿病中的波动
5. Regulation of glucose-dependent insulinotropic polypeptide (GIP) receptor expression in the pancreatic beta-cell. [D] . Lynn, Francis Christopher. 2003

机译：胰岛β细胞中葡萄糖依赖性促胰岛素多肽（GIP）受体表达的调节。
6. The Incretins and Pancreatic β-Cells: Use of Glucagon-Like Peptide-1 and Glucose-Dependent Insulinotropic Polypeptide to Cure Type 2 Diabetes Mellitus [O] . Mi-Hyun Kim, Moon-Kyu Lee 2010

机译：肠抑素和胰腺β细胞：使用胰高血糖素样肽1和葡萄糖依赖性促胰岛素多肽治疗2型糖尿病。
7. Four weeks of near-normalisation of blood glucose improves the insulin response to glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide in patients with type 2 diabetes [O] . P. V. Højberg, T. Vilsbøll, R. Rabøl, 2008

机译：血糖的近期正常化四周改善了2型糖尿病患者对胰高血糖素样肽-1和葡萄糖依赖性胰岛素的多肽的胰岛素反应

Four weeks of near-normalisation of blood glucose improves the insulin response to glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide in patients with type 2 diabetes

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