...
首页> 外文期刊>Digestive Diseases and Sciences >Sphingosine-1-Phosphate Regulates the Expression of Adherens Junction Protein E-Cadherin and Enhances Intestinal Epithelial Cell Barrier Function
【24h】

Sphingosine-1-Phosphate Regulates the Expression of Adherens Junction Protein E-Cadherin and Enhances Intestinal Epithelial Cell Barrier Function

机译:1磷酸鞘氨醇调节粘附连接蛋白E-钙黏着蛋白的表达并增强肠上皮细胞屏障功能

获取原文
获取原文并翻译 | 示例
           

摘要

The regulation of intestinal barrier permeability is important in the maintenance of normal intestinal physiology. Sphingosine-1-phosphate (S1P) has been shown to play a pivotal role in enhancing barrier function in several non-intestinal tissues. The current study determined whether S1P regulated function of the intestinal epithelial barrier by altering expression of E-cadherin, an important protein in adherens junctions.
机译:肠屏障通透性的调节在维持正常肠生理中很重要。鞘氨醇-1-磷酸酯(S1P)已显示在几种非肠道组织中增强屏障功能中起关键作用。当前的研究确定了S1P是否通过改变E-cadherin的表达来调节肠上皮屏障的功能,E-cadherin是粘附连接中的重要蛋白。

著录项

  • 来源
    《Digestive Diseases and Sciences》 |2011年第5期|p.1342-1353|共12页
  • 作者单位

    Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA;

    Department of Surgery, Baltimore Veterans Affairs Medical Center, 10 N. Greene Street, Baltimore, MD, 21201, USA;

    Department of Surgery, Baltimore Veterans Affairs Medical Center, 10 N. Greene Street, Baltimore, MD, 21201, USA;

    Department of Surgery, Baltimore Veterans Affairs Medical Center, 10 N. Greene Street, Baltimore, MD, 21201, USA;

    Department of Gastroenterology, University of Maryland School of Medicine, Baltimore, MD, USA;

    Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA;

    Department of Gastroenterology, University of Maryland School of Medicine, Baltimore, MD, USA;

    Department of Surgery, Baltimore Veterans Affairs Medical Center, 10 N. Greene Street, Baltimore, MD, 21201, USA;

    Department of Surgery, Baltimore Veterans Affa;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Sphingosine; Intestinal barrier; Ca2+ signaling; Intestinal epithelium;

    机译:鞘氨醇;肠屏障;Ca2 +信号传导;肠上皮;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号