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13C-Urea Breath Test Values and Helicobacter pylori Eradication

机译：13 C-尿素呼气试验值与根除幽门螺杆菌

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摘要

Delta over baseline (DOB) values of 13C-urea breath test (UBT) have been shown to be predictive of H. pylori eradication following therapy. This was a post hoc analysis of a large, double-blind, randomized trial. Consecutive patients with a positive UBT underwent upper endoscopy. H. pylori strains were tested for clarithromycin resistance. All patients received an eradication therapy with either a standard 10-day triple therapy or a 10-day sequential regimen. The infection was considered cured when two consecutive UBTs were negative. Basal DOB values were categorized as low (35). A total of 282 patients were selected. Eradication rates did not differ between patients with high and low DOB values. No significant difference in DOB values emerged between patients infected with clarithromycin-susceptible and clarithromycin-resistant strains. Under multivariate analysis, DOB values did not influence the bacterial eradication, which was significantly affected only by the presence of clarithromycin resistance. This large analysis failed to demonstrate a role for DOB value in H. pylori eradication with either a 10-day triple or sequential therapy.
机译：研究表明， 13 C-尿素呼气试验（UBT）的超过基线（DOB）的Delta值可预测幽门螺杆菌的根除。这是一项大型，双盲，随机试验的事后分析。 UBT阳性的连续患者接受上内镜检查。测试幽门螺杆菌菌株对克拉霉素的抗性。所有患者均接受标准10天三联疗法或10天序贯方案根除疗法。当两个连续的UBT阴性时，感染被认为已治愈。基础DOB值分类为低（35）。总共选择了282例患者。 DOB值高低的患者的根除率没有差异。在感染了克拉霉素敏感性和克拉霉素耐药菌株的患者之间，DOB值无显着差异。在多变量分析中，DOB值不影响细菌的根除，而细菌根除仅受到克拉霉素抗性的显着影响。这项大型分析未能证明DOB值在采用10天三联疗法或序贯疗法根除幽门螺杆菌中的作用。

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