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13C-urea breath test values and Helicobacter pylori eradication.

机译：13C-尿素呼吸试验值和幽门螺杆菌根除。

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摘要

Delta over baseline (DOB) values of 13C-urea breath test (UBT) have been shown to be predictive of H. pylori eradication following therapy. This was a post hoc analysis of a large, double-blind, randomized trial. Consecutive patients with a positive UBT underwent upper endoscopy. H. pylori strains were tested for clarithromycin resistance. All patients received an eradication therapy with either a standard 10-day triple therapy or a 10-day sequential regimen. The infection was considered cured when two consecutive UBTs were negative. Basal DOB values were categorized as low (<16), intermediate (16-35), or high (>35). A total of 282 patients were selected. Eradication rates did not differ between patients with high and low DOB values. No significant difference in DOB values emerged between patients infected with clarithromycin-susceptible and clarithromycin-resistant strains. Under multivariate analysis, DOB values did not influence the bacterial eradication, which was significantly affected only by thepresence of clarithromycin resistance. This large analysis failed to demonstrate a role for DOB value in H. pylori eradication with either a 10-day triple or sequential therapy.
机译：在治疗后，已显示13C-尿素呼气测试（UBT）的基线（DOB）值的达达拉值。这是对大型双盲，随机试验的后HOC分析。连续UBT接受上内窥镜检查的患者。 H.测试幽门螺杆菌菌株对克拉霉素抗性。所有患者都接受了根除治疗，其标准的10天三疗法或10天顺序方案。当两个连续的Ubts阴性时，被认为是治愈的感染。基础DOB值被分类为低（<16），中间体（16-35）或高（> 35）。共选出282名患者。在高DOB值和低DOB值之间的患者之间根除率没有差异。在感染克拉霉素易感和克拉霉素抗性菌株的患者之间出现的DOB值没有显着差异。在多变量分析下，DOB值没有影响细菌根除，这才受到克拉霉素抗性的阶段显着影响。这种大的分析未能在H.幽门螺杆菌中展示DOB值的作用，其中包含10天的三元或连续治疗。

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