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首页> 外文期刊>Digestive Diseases and Sciences >Effects of L-Carnitine on Oxidant/Antioxidant Status in Acetic Acid-Induced Colitis
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Effects of L-Carnitine on Oxidant/Antioxidant Status in Acetic Acid-Induced Colitis

机译：左旋肉碱对乙酸诱导的结肠炎的氧化/抗氧化状态的影响

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摘要

Recently, the role of oxidative stress in the pathogenesis of ulcerative colitis has been investigated. This study was designed to evaluate the possible beneficial effects of L-carnitine on tissue injury and oxidative stress in acetic acid-induced colitis in rats. Acetic acid administration induced severe damage macroscopically and histopathologically in colon and significantly increased the levels of malondialdehyde and myeloperoxidase in colonic tissue. Supplementation of L-carnitine to acetic acid-treated rats did not prove to induce any improvements in macroscopic scores, while L-carnitine administration improved histopathologic scores and significantly decreased malondialdehyde and myeloperoxidase levels in treatment groups. Acetic acid administration significantly decreased reduced glutathione, superoxide dismutase, and catalase levels in colonic homogenate. Supplementation of L-carnitine prevented the depletion of reduced glutathione levels but significantly increased superoxide dismutase levels. On the other hand, no significant change in catalase activity was observed. In conclusion, these results may reflect that L-carnitine could be beneficial as a complementary agent in treatment of ulcerative colitis.
机译：最近，已经研究了氧化应激在溃疡性结肠炎的发病机理中的作用。本研究旨在评估左旋肉碱对乙酸诱导的大鼠结肠炎组织损伤和氧化应激的可能有益作用。醋酸在结肠的宏观和组织病理学上引起严重损害，并显着增加结肠组织中丙二醛和髓过氧化物酶的水平。向醋酸治疗的大鼠补充左旋肉碱并不能证明在宏观评分上有任何改善，而左旋肉碱的给药可以改善组织病理学评分，并显着降低治疗组的丙二醛和髓过氧化物酶水平。服用醋酸可显着降低结肠匀浆中谷胱甘肽，超氧化物歧化酶和过氧化氢酶水平的降低。补充左旋肉碱可以防止减少的谷胱甘肽水平下降，但会显着增加超氧化物歧化酶水平。另一方面，未观察到过氧化氢酶活性的显着变化。总之，这些结果可能反映出左旋肉碱作为溃疡性结肠炎的补充剂可能是有益的。

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