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首页> 外文期刊>Digestive Diseases and Sciences >Intestinal Blood Flow in Murine Colitis Induced with Dextran Sulfate Sodium
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Intestinal Blood Flow in Murine Colitis Induced with Dextran Sulfate Sodium

机译：硫酸右旋糖酐钠诱导的小鼠结肠炎肠道血流

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The aim of this study was to assess whether colitis induced by dextran sulfate sodium (DSS; 10% in tap water for 7 days) in BALB/c mice is associated with changes in intestinal blood flow. After anaesthesia, systemic hemodynamic variable and regional blood flows and resistances in various organs were measured in both control and DSS-treated mice. Mean arterial blood pressure was significantly lower in DSS-treated mice than in controls (56 ± 4 vs 66 ± 3 mm Hg; P < 0.05), but no differences were found in regional blood flows to or vascular resistances in the lungs, liver, stomach, small intestine (upper, middle, and lower part), cecum, mesentery + pancreas, spleen, kidneys, brain, and skin. However, compared to the control mice, blood flows in the middle (0.88 ± 0.13 vs 0.55 ± 0.09 ml/min/g; P < 0.05) and distal (0.69 ± 0.11 vs 0.29 ± 0.05 ml/min/g; P < 0.05) colon were significantly higher, and vascular resistances in the proximal (0.87 ± 0.21 vs 1.36 ± 0.21 mm Hg min/ml/100 g; P < 0.05), middle (0.60 ± 0.10 vs 1.46 ± 0.35 mm Hg min/ml 100 g; P < 0.05) as well as distal (0.90 ± 0.25 vs 2.67 ± 0.49 mm Hg min/ml/100 g; P < 0.05) colon were significantly lower in mice with experimental colitis. Interestingly, there was a gradient in the intestinal blood flow in control mice from the upper small intestine (2.79 ± 0.72 ml/min/g) down to the distal colon (0.29 ± 0.05 ml/min/g); such a gradient was also present in the colitis mice. It is concluded that DSS-induced colitis in mice is associated with microcirculatory disturbances in the colon, mainly in its middle and distal parts.
机译：这项研究的目的是评估BALB / c小鼠中由硫酸葡聚糖钠（DSS； 10％在自来水中7天）诱导的结肠炎是否与肠道血流变化相关。麻醉后，在对照和DSS治疗的小鼠中测量全身血液动力学变量以及各器官中的局部血流和阻力。 DSS处理的小鼠的平均动脉压明显低于对照组（56±4 vs 66±3 mm Hg； P <0.05），但在肺，肝，胃，小肠（上部，中部和下部），盲肠，肠系膜+胰腺，脾脏，肾脏，大脑和皮肤。但是，与对照组小鼠相比，中部（0.88±0.13 vs 0.55±0.09 ml / min / g； P <0.05）和远端（0.69±0.11 vs 0.29±0.05 ml / min / g； P <0.05）的血液流动）结肠明显更高，近端的血管阻力（0.87±0.21 vs 1.36±0.21 mm Hg min / ml / 100 g; P <0.05），中层（0.60±0.10 vs 1.46±0.35 mm Hg min / ml 100 g ； P <0.05）以及远端结肠癌（0.90±0.25 vs 2.67±0.49 mm Hg min / ml / 100 g； P <0.05）结肠癌小鼠的结肠癌明显降低。有趣的是，对照组小鼠的肠血流量从上小肠（2.79±0.72 ml / min / g）到远端结肠（0.29±0.05 ml / min / g）呈梯度变化。在结肠炎小鼠中也存在这种梯度。结论是，DSS诱发的小鼠结肠炎与结肠的微循环障碍有关，主要在结肠的中部和远端。

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