Human Embryo Gets CRISPR Treatment

ERIC BETZ

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Human Embryo Gets CRISPR Treatment

机译：人类胚胎接受CRISPR治疗

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IN JUST A FEW SHORT YEARS, the gene-editing tool CRISPR-Cas9 has infiltrated biology labs around the world. This summer, scientists working in a U.S. lab announced they'd used CRISPR to modify viable human embryos, which were kept alive just a few days. The research is a first in the United States, though scientists in China have conducted similar experiments. This latest effort, led by researchers at Oregon Health and Science University, also succeeded in avoiding unintended effects - something that's plagued other researchers. The team fixed a mutation by removing a disease-causing gene from an embryo. The repair, reported in August in Nature, corrected an inheritable heart condition, passed down by the embryo's father, the study's lone sperm donor.

机译：在短短的几年内，基因编辑工具CRISPR-Cas9已渗透到世界各地的生物学实验室。今年夏天，在美国实验室工作的科学家宣布，他们已经使用CRISPR修饰了能存活几天的人类胚胎。这项研究在美国尚属首次，尽管中国的科学家已经进行了类似的实验。由俄勒冈州健康与科学大学的研究人员领导的这项最新努力也成功避免了意想不到的影响，这困扰了其他研究人员。研究小组通过从胚胎中去除致病基因来修复突变。这项修复报告于八月在《自然》杂志上发表，纠正了可遗传的心脏病，该疾病被该研究的唯一的精子捐献者胚胎的父亲传下来。

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《Discover》 |2018年第1期|16-16|共1页
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ERIC BETZ;
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1. Towards a CRISPR view of early human development: applications, limitations and ethical concerns of genome editing in human embryos [J] . Reyes Alvaro Plaza, Lanner Fredrik Development . 2017,第1期

机译：朝着早期人类发展的清晰视图：人类胚胎中基因组编辑的应用，限制和伦理问题
2. CRISPR EDITING WREAKS CHROMOSOMAL MAYHEM IN HUMAN EMBRYOS [J] . Ledford Heidi Nature . 2020,第7814期

机译：Crispr编辑在人胚胎中污染染色体mayhem
3. Gene Editing of Human Embryos with CRISPR/Cas9: Great Promise Coupled with Important Caveats [J] . Diana Schenkwein, Seppo Yl?-Herttuala Molecular therapy: the journal of the American Society of Gene Therapy . 2018,第3期

机译：用CRISPR / CAS9的人类胚胎的基因编辑：伟大的希望与重要的警告相结合
4. Automated Embryo Stage Classification in Time-Lapse Microscopy Video of Early Human Embryo Development [C] . Yu Wang, Farshid Moussavi, Peter Lorenzen International conference on medical imaging computing and computer-assisted intervention . 2013

机译：早期人类胚胎发育的延时显微镜视频中的自动胚胎阶段分类
5. Ethics of the Inheritable Genetic Modification of Human Embryos via CRISPR Technology: Pauli Murray and the Institutionalized Control of Black Women’s Reproductive Lives [D] . Metcalfe, Darcy. 2021

机译：通过CRISPR技术的人类胚胎具有可遗传遗传修饰的伦理：Pauli Murray和黑人女性生殖生活的制度化控制
6. CRISPRs for Optimal Targeting: Delivery of CRISPR Components as DNA RNA and Protein into Cultured Cells and Single-Cell Embryos [O] . Evguenia Kouranova, Kevin Forbes, Guojun Zhao, -1

机译：CRISPR的最佳靶向：将CRISPR成分（如DNARNA和蛋白质）输送到培养的细胞和单细胞胚胎中
7. Towards a CRISPR view of early human development: applications, limitations and ethical concerns of genome editing in human embryos [O] . Alvaro Plaza Reyes, Fredrik Lanner 2017

机译：朝着早期人类发展的清晰视图：人类胚胎中基因组编辑的应用，限制和伦理问题

Human Embryo Gets CRISPR Treatment

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