Lithium Treatment For Als

Jane Bosveld

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Lithium Treatment For Als

机译：铝锂处理

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Few diseases are as devastating as the progressive neurodegenerative disease ALS (amyotrophic lateral sclerosis), also known as Lou Gehrig's disease. Over time, a patient with ALS will lose almost all ability to move. The paralysis is caused by the gradual death of the neurons that control movement. Just one FDA-approved drug, riluzole, has been shown to slow the disease's progression-and only minimally. Now a small study suggests how treatment might be improved. In a February report in Proceedings of the National Academy of Sciences, Francesco Fornai, an anatomy professor and physician at the University of Pisa, found that lithium-well known as a treatment for bipolar disorder-might also work against ALS.

机译：很少有疾病像进行性神经退行性疾病ALS（肌萎缩性侧索硬化）一样具有毁灭性，也被称为Lou Gehrig's病。随着时间的流逝，患有ALS的患者将失去几乎所有的移动能力。瘫痪是由控制运动的神经元逐渐死亡引起的。已显示，只有一种FDA批准的药物riluzole可以减缓疾病的发展，而且速度很小。现在，一项小型研究提出了如何改善治疗的建议。比萨大学的解剖学教授兼医师弗朗切斯科·佛奈（Francesco Fornai）在2月的《美国国家科学院院刊》（National Academy of Sciences）中发表报告，发现众所周知的锂离子疗法也可能对抗ALS。

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《Discover》 |2009年第1期|p.40|共1页
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Jane Bosveld;
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1. Lithium treatment moderate-dose use study (LiTMUS) for bipolar disorder: A randomized comparative effectiveness trial of optimized personalized treatment with and without lithium [J] . NierenbergA.A., theUniversityofPittsburghSchoolofMedicineUnitedStatesofAmerica, theUniversityofTexasHealthScienceCenterSanAntonio, American journal of psychiatry . 2013,第1期

机译：锂离子疗法治疗双相情感障碍的中剂量使用研究（LiTMUS）：优化的个性化治疗（含或不含锂）的随机比较有效性试验
2. The association of the effect of lithium in the maintenance treatment of bipolar disorder with lithium plasma levels: A post hoc analysis of a double-blind study comparing switching to lithium or placebo in patients who responded to quetiapine (Trial 144) [J] . NolenW.A., WeislerR.H. Bipolar disorders. . 2013,第1期

机译：锂在双相情感障碍维持治疗中的作用与锂血浆水平的关联：一项对喹硫平有反应的患者改用锂或安慰剂的双盲研究的事后分析（试验144）
3. Influence of lithium chloride, lithium bromide and lithium fluoride additives on performance of polyethersulfone membranes and its application in the treatment of palm oil mill effluent [J] . Ani Idris, Iqbal Ahmed, Mazaitul Asmah Limin Desalination: The International Journal on the Science and Technology of Desalting and Water Purification . 2010,第2期

机译：氯化锂，溴化锂和氟化锂添加剂对聚醚砜膜性能的影响及其在棕榈油厂废水处理中的应用
4. DEUTERIUM TREATMENT EFFECTS ON LITHIUM AND TIN-LITHIUM SPUTTERING IN SOLID AND LIQUID PHASE [C] . J.P. ALLAIN, D.N. RUZIC International NATO advanced research workshop on hydrogen and helium recycling at plasma facing materials . 2002

机译：固体和液相中锂和锡锂溅射的氘处理效果
5. The transition from localized corrosion to SCC of aluminum-lithium-copper alloy AA2096 as a function of isothermal aging heat treatment at 160 degrees Celsius. [D] . Connolly, Brian Joseph. 2002

机译：铝锂铜合金AA2096从局部腐蚀到SCC的转变是在160摄氏度下等温时效热处理的函数。
6. Socio-demographic and clinical predictors of outcome to long-term treatment with lithium in bipolar disorders: a systematic review of the contemporary literature and recommendations from the ISBD/IGSLI Task Force on treatment with lithium [O] . Diane Grillault Laroche, Bruno Etain, Emanuel Severus, 2020

机译：双极性疾病锂长期治疗结果的社会人口统计学和临床预测：对锂锂治疗ISBD / IGSLI任务组的当代文学和建议的系统审查
7. The association of the effect of lithium in the maintenance treatment of bipolar disorder with lithium plasma levels:a post hoc analysis of a double-blind study comparing switching to lithium or placebo in patients who responded to quetiapine (Trial 144) [O] . Nolen Willem A., Weisler Richard H. 2013

机译：锂在双相情感障碍维持治疗中的作用与锂血浆水平的关联：一项对喹硫平有反应的患者改用锂或安慰剂的双盲研究的事后分析（试验144）
8. Identification and treatment of lithium as the primary toxicant in a groundwater treatment facility effluent [R] . Kszos, L. A. , Crow, K. R. 1996

机译：确定和处理锂作为地下水处理设施污水中的主要毒物

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