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首页> 外文期刊>DNA and Cell Biology >Gene Structure and Chromosomal Assignment of Mouse GITR, a Member of the Tumor Necrosis Factor/Nerve Growth Factor Receptor Family
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Gene Structure and Chromosomal Assignment of Mouse GITR, a Member of the Tumor Necrosis Factor/Nerve Growth Factor Receptor Family

机译：小鼠GITR，肿瘤坏死因子/神经生长因子受体家族成员的基因结构和染色体分配

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摘要

GITR is a type I transmembrane protein that belongs to the tumor necrosis factorerve growth factor receptor (TNF/NGFR) family. This receptor is preferentially expressed in activated T lymphocytes and may function as signaling molecule during T-cell development. In the present study, we examined the genomic organization of the entire mouse GITR (mGITR) gene. The gene spans a 2543-bp region and consists of five exons (with a length ranging from 88 bp to 395 bp) and four introns (67 bp to 778 bp). In agreement with GITR expression in activated T cells, consensus elements for transcription factors involved in T-cell development and activation were identified in the 5' flanking region, including a consensus element for NF-kappaB. Two highly significant binding sites for MyoD and one binding site for myogenin were also found, suggesting involvement of GITR in muscle development. The mGITR gene contains 17 transcription initiation sites distributed over a 76-bp region, all used with the same frequency. We localized mGITR to the murine chromosome 4 (E region), where other 4 TNF/NGFR members localize, including m4-1BB and mOX40i. These results further indicate that GITR shares several features with OX40, 4-1BB, and CD27, suggesting the existence of a new subfamily of the TNFR family, as also confirmed by the similarity of their cytoplasmic domains.
机译：GITR是一种I型跨膜蛋白，属于肿瘤坏死因子/神经生长因子受体（TNF / NGFR）家族。该受体优先在活化的T淋巴细胞中表达，并可能在T细胞发育过程中充当信号分子。在本研究中，我们检查了整个小鼠GITR（mGITR）基因的基因组组织。该基因跨越2543 bp区域，由5个外显子（长度在88 bp至395 bp之间）和4个内含子（67 bp至778 bp）组成。与激活的T细胞中的GITR表达一致，在5'侧翼区域鉴定了参与T细胞发育和激活的转录因子的共有元件，包括NF-κB的共有元件。还发现了两个非常重要的MyoD结合位点和一个肌生成素的结合位点，表明GITR参与了肌肉发育。 mGITR基因包含分布在76 bp区域的17个转录起始位点，全部以相同的频率使用。我们将mGITR定位于鼠染色体4（E区），其中其他4个TNF / NGFR成员位于其中​​，包括m4-1BB和mOX40i。这些结果进一步表明，GITR与OX40、4-1BB和CD27具有多个特征，这表明存在TNFR家族的新亚家族，这也被其胞质结构域的相似性所证实。

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