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首页> 外文期刊>Documenta Ophthalmologica >Pattern electroretinogram optimized for glaucoma screening (PERGLA) and retinal nerve fiber thickness in suspected glaucoma and ocular hypertension
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Pattern electroretinogram optimized for glaucoma screening (PERGLA) and retinal nerve fiber thickness in suspected glaucoma and ocular hypertension

机译：针对可疑青光眼和高眼压的青光眼筛查（PERGLA）和视网膜神经纤维厚度优化的模式视网膜电图

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The purpose of this study is to evaluate pattern electroretinogram optimized for glaucoma screening (PERGLA) and retinal nerve fiber layer (RNFL) at spectral optical coherence tomography (OCT) in eyes with suspected glaucoma (GS) and in eyes with ocular hypertension (OHT). This is a cross-sectional, observational study. Twenty-four patients with GS (BCVA 20/20, normal visual field, intraocular pressure, IOP, less than 21 mmHg, and glaucomatous optic neuropathy, GON) and 14 patients with OHT (BCVA 20/20, intraocular pressure 25 mmHg, absence of glaucomatous optic neuropathy and normal visual field) were considered in this study. GON was intended as vertical cup-disk ratio of 0.5 or more; asymmetry of greater than 0.2, disk notching, disk splinter hemorrhages. PERGLA amplitude and phase were measured, while thickness of the RNFL was obtained with spectral OCT. A control group of 50 age-matched healthy patients was added. In the GS group, 16 eyes (66.7%) showed normal average RNFL analysis and normal PERGLA, 3 eyes (12.5%) showed abnormal average RNFL analysis and abnormal PERGLA, 5 eyes (20.8%) presented with normal average RNFL analysis and abnormal PERGLA. In the OHT group, 11 eyes (78.6%) showed an average normal RNFL and normal PERGLA, while 3 eyes (21.4%) presented with an average normal RNFL and abnormal PERGLA. PERGLA is a non-invasive, fast, and fully automatic version of the pattern ERG. In eyes with OHT and in eyes with GS, PERGLA abnormalities in presence of a normal RNFL could suggest an early functional damage of viable retinal ganglion cells.
机译：这项研究的目的是评估可疑青光眼（GS）和高眼压（OHT）眼睛在光谱光学相干断层扫描（OCT）时针对青光眼筛查（PERGLA）和视网膜神经纤维层（RNFL）优化的模式视网膜电图。这是一项横断面的观察性研究。 24例GS患者（BCVA 20/20，视野正常，眼内压，IOP，小于21 mmHg和青光眼性视神经病变GON）和14例OHT患者（BCVA 20/20，眼内压25 mmHg，无本研究考虑了青光眼性视神经病变和正常视野的影响。 GON的垂直杯盘比为0.5或更高；不对称度大于0.2，出现椎间盘切迹，椎间盘碎片出血。测量了PERGLA的振幅和相位，同时使用光谱OCT获得了RNFL的厚度。加入50名年龄匹配的健康患者作为对照组。 GS组中，平均RNFL分析正常且PERGLA正常的有16眼（66.7％），平均RNFL分析异常且PERGLA异常的有3眼（12.5％），平均RNFL分析异常且PERGLA正常的有5眼（20.8％）。 。在OHT组中，有11眼（78.6％）的RNFL和PERGLA平均正常，而有3眼（21.4％）的RNFL和PERGLA正常。 PERGLA是模式ERG的非侵入性，快速且全自动版本。在OHT眼和GS眼中，在正常RNFL存在的情况下，PERGLA异常可能提示存活的视网膜神经节细胞早期功能受损。

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