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Amid the brouhaha surrounding the Human Genome Project and its commercial rivals, the fact that there is more than one way to map a genome has got rather lost. Physical mapping, as the Human Genome Project approach is known, relies on chopping genetic material into pieces, and working out the order of the nucleotide bases (the chemical "letters" in which the genetic message is spelled out) of each piece. Computers then fit the sequences of the separate pieces back together by finding overlaps between them and, presto!, the sequence can be read. Physical maps tell you a lot. But they cannot tell you everything. It is hard, for instance, to use them to find associations between particular versions of genes (alleles, in the jargon) and the diseases that those alleles might cause. For that, a second type of genetic cartography is better-so-called linkage mapping.
机译:在围绕人类基因组计划及其商业竞争者的激烈讨论中,绘制基因组的方法不止一种,这一事实已经相当失传了。正如人类基因组计划(Human Genome Project)方法所知,物理作图依赖于将遗传物质切成碎片,并计算出每个碎片的核苷酸碱基顺序(拼写出遗传信息的化学“字母”)。然后,计算机通过查找独立片段之间的重叠将它们的序列重新组合在一起,从而可以读取序列。实物图告诉您很多。但是他们无法告诉您一切。例如,很难用它们来发现基因的特定版本(行话中的等位基因)与那些等位基因可能引起的疾病之间的关联。为此,遗传制图的第二种类型是所谓的连锁映射。

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