...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Ecotoxicology and Environmental Safety >Directly repurposing waste optical discs with prefabricated nanogrooves as a platform for investigation of cell-substrate interactions and guiding neuronal growth
【24h】

Directly repurposing waste optical discs with prefabricated nanogrooves as a platform for investigation of cell-substrate interactions and guiding neuronal growth

机译：用预制的纳米槽直接重新利用废弃的光盘，作为研究细胞-底物相互作用并指导神经元生长的平台

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Due to rapid change in information technology, many consumer electronics become electronic waste which is the fastest-growing pollution problems worldwide. In fact, many discarded electronics with prefabricated microanostructures may provide a good basis to fulfill special needs of other fields, such as tissue engineering, biosensors, and energy. Herein, to take waste optical discs as an example, we demonstrate that discarded electronics can be directly repurposed as highly anisotropic platforms for in vitro investigation of cell behaviors, such as cell adhesion, cell alignment, and cell-cell interactions. The PC12 cells cultured on biocompatible DVD polycarbonate layers with flat and grooved morphology show a distinct cell morphology, indicating the topographical cue of nanogrooves plays a key role in guidance of neurites growth. By further monitoring cell morphology and alignment of PC12 cells cultured on the DVD nanogrooves at different differentiation times, we find that cell contact interaction with nanotopographies is dynamically adjustable with differentiation time from initial disorder to final order. This study adds a new dimension to not only solving the problems of supply of materials and fabrication of nanopatterns in neural tissue engineering, but may also offering a new promising way of waste minimization or reuse for environmental protection.
机译：由于信息技术的快速变化，许多消费电子产品成为电子废物，这是全球增长最快的污染问题。实际上，许多废弃的具有预制微/纳米结构的电子产品可能为满足其他领域（例如组织工程，生物传感器和能源）的特殊需求提供了良好的基础。在这里，以废光盘为例，我们证明了废弃的电子设备可以直接用作高度各向异性的平台，用于体外研究细胞行为，例如细胞粘附，细胞排列和细胞间相互作用。在具有平坦和凹槽形态的生物相容性DVD聚碳酸酯层上培养的PC12细胞显示出独特的细胞形态，表明纳米凹槽的形貌线索在神经突生长的指导中起着关键作用。通过进一步监测细胞形态和在不同分化时间在DVD纳米槽上培养的PC12细胞的排列，我们发现与纳米形貌的细胞接触相互作用可以随着从初始疾病到最终次序的分化时间而动态调节。这项研究不仅为解决神经组织工程中材料的供应和纳米图案的制造问题提供了新的维度，而且还可能提供一种将废物最小化或用于环境保护的新的有希望的方法。

著录项

  • 来源
    《Ecotoxicology and Environmental Safety》 |2018年第9期|273-281|共9页
  • 作者

    Lu Jiao Yang; Zhu Qiu Yan; Zhang Xin Xing; Zhang Fu Rui; Huang Wei Tao; Ding Xue Zhi; Xia Li Qiu; Luo Hong Qun; Li Nian Bing;

  • 作者单位

    Hunan Normal Univ, Coll Life Sci, State Key Lab Dev Biol Freshwater Fish, Changsha 410081, Hunan, Peoples R China;

    Hunan Normal Univ, Coll Life Sci, State Key Lab Dev Biol Freshwater Fish, Changsha 410081, Hunan, Peoples R China;

    Hunan Normal Univ, Coll Life Sci, State Key Lab Dev Biol Freshwater Fish, Changsha 410081, Hunan, Peoples R China;

    Hunan Normal Univ, Coll Life Sci, State Key Lab Dev Biol Freshwater Fish, Changsha 410081, Hunan, Peoples R China;

    Hunan Normal Univ, Coll Life Sci, State Key Lab Dev Biol Freshwater Fish, Changsha 410081, Hunan, Peoples R China;

    Hunan Normal Univ, Coll Life Sci, State Key Lab Dev Biol Freshwater Fish, Changsha 410081, Hunan, Peoples R China;

    Hunan Normal Univ, Coll Life Sci, State Key Lab Dev Biol Freshwater Fish, Changsha 410081, Hunan, Peoples R China;

    Southwest Univ, Sch Chem & Chem Engn, Minist Educ, Key Lab Ecoenvironm Three Gorges Reservoir Reg, Chongqing 400715, Peoples R China;

    Southwest Univ, Sch Chem & Chem Engn, Minist Educ, Key Lab Ecoenvironm Three Gorges Reservoir Reg, Chongqing 400715, Peoples R China;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Electronic waste; Nanopattems; Neuronal guidance; Neuronal tissue engineering; PC12 cells;

    机译：电子废物;纳米模式;神经引导;神经组织工程;PC12细胞;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号