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首页> 外文期刊>Ecotoxicology and Environmental Safety >Linking mobile source-PAHs and biological effects in traffic police officers and drivers in Rawalpindi (Pakistan)
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Linking mobile source-PAHs and biological effects in traffic police officers and drivers in Rawalpindi (Pakistan)

机译：将移动源PAHs与拉瓦尔品第（巴基斯坦）的交通警察和驾驶员中的生物效应联系起来

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The aim of this study was to evaluate the effect of traffic related polycyclic aromatic hydrocarbons (PAHs) on blood parameters of subjects, including traffic police officers (TP), drivers (DR) and control subjects (CN) with presumably different levels of exposure. We quantified the urinary 1-hydroxypyrene (1-OH-Pyr), alpha-naphthol and beta-naphthol (alpha- and beta-naph) as biomarkers of exposure to PAHs in relation with biomarkers of effect (Hb, MCV, PCV, PLT, RBCs), biomarkers of inflammation/infection (CRP, WBCs), oxidative stress (SOD) and oxidative DNA damage i.e. 8-hydroxy-2-deoxyguanosine (8-OHdG). Results showed that mean 1-OHPyr, alpha-naph and beta-naph concentrations were significantly higher in TPs (0.98, 1.55, and 1.9 umol mol-Cr-1, respectively, p < 0.05) than CNs (0.7, 0.6; 0.67 pmol mol-Cr-1 respectively, P < 0.05). Furthermore, WBC and CRP were found in higher concentrations in TPs than CNs (7.04 x 10(3) mu L-1 and 0.95 mg L-1 vs. 5.1 x 10(3) mu L-1 and 0.54 mg L-1, respectively). The urinary 8-OHdG level, a biomarker of oxidative DNA damage, was higher in TPs than both CN and DR subjects (48 ng mg-Cr-1, 24 ng mg-Cr-1 and 33 ng mg-Cr-1, respectively). Self-reported health assessment indicates that, on the basis of daily time spent in the middle of heavy traffic, TPs and DRs more frequently suffered from adverse head and respiratory symptoms. The PCA analysis evidenced the impact of traffic pollution on exposure biomarkers and DNA damage. The study suggests that traffic pollution may be associated with important health risk, in particular on the respiratory system, not only for workers exposed to traffic exhausts but also for general public. Finally, vehicular air pollution in the city of Rawalpindi should be a high-priority concern for the Pakistan Government that needs to be addressed. (C) 2016 Published by Elsevier Inc.
机译：这项研究的目的是评估与交通有关的多环芳烃（PAHs）对受试者的血液参数的影响，这些受试者包括可能具有不同暴露水平的交通警察（TP），驾驶员（DR）和对照受试者（CN）。我们将尿中的1-羟基py（1-OH-Pyr），α-萘酚和β-萘酚（α-和β-萘酚）量化为暴露于PAHs的生物标志物，并将其与效应生物标志物相关（Hb，MCV，PCV，PLT （RBC），炎症/感染（CRP，WBC），氧化应激（SOD）和氧化性DNA损伤（即8-羟基-2-脱氧鸟苷（8-OHdG））的生物标志物。结果显示，TPs中的1-OHPyr，α-naph和β-naph的平均浓度（分别为0.98、1.55和1.9 umol mol-Cr-1）显着高于CNs（0.7、0.6; 0.67 pmol） mol-Cr-1分别为P <0.05）。此外，发现TP中的WBC和CRP的浓度高于CNs（7.04 x 10（3）μL-1和0.95 mg L-1，而5.1 x 10（3）μL-1和0.54 mg L-1，分别）。 TPs中的尿中的8-OHdG水平是氧化性DNA损伤的生物标志物，高于CN和DR受试者（分别为48 ng mg-Cr-1、24 ng mg-Cr-1和33 ng mg-Cr-1 ）。自我报告的健康评估表明，根据繁忙时间每天所花费的时间，TP和DR更常遭受不良的头部和呼吸道症状。 PCA分析证明了交通污染对暴露生物标志物和DNA损伤的影响。该研究表明，交通污染可能与重要的健康风险有关，特别是在呼吸系统上，不仅对暴露于交通尾气的工人，而且对公众也是如此。最后，拉瓦尔品第市的汽车空气污染应成为巴基斯坦政府的高度优先事项，需要予以解决。 （C）2016由Elsevier Inc.发布

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