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Integration of metabolic and cardiovascular diurnal rhythms by circadian clock

机译：昼夜节律时钟整合代谢和心血管昼夜节律

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摘要

Understanding how the 24-hour blood-pressure rhythm is programmed has been one of the most challenging questions in cardiovascular research. The 24-hour blood-pressure rhythm is primarily driven by the circadian clock system, in which the master circadian pacemaker within the suprachiasmatic nuclei of the hypothalamus is first entrained to the light/dark cycle and then transmits synchronizing signals to the peripheral clocks common to most tissues, including the heart and blood vessels. However, the circadian system is more complex than this basic hierarchical structure, as indicated by the discovery that peripheral clocks are either influenced to some degree or fully driven by temporal changes in energy homeostasis, independent of the light entrainment pathway. Through various comparative genomic approaches and through studies exploiting mouse genetics and transgenics, we now appreciate that cardiovascular tissues possess a large number of metabolic genes whose expression cycle and reciprocally affect the transcriptional control of major circadian clock genes. These findings indicate that metabolic cycles can directly or indirectly affect the diurnal rhythm of cardiovascular function. Here, we discuss a framework for understanding how the 24-hour blood-pressure rhythm is driven by the circadian system that integrates cardiovascular and metabolic function.
机译：了解24小时血压节律的编程方式是心血管研究中最具挑战性的问题之一。 24小时血压节律主要由生物钟系统驱动，在该系统中，下丘脑上视交叉核内的主要生物钟起搏器首先被带入明/暗周期，然后将同步信号传输到通用的外围时钟大多数组织，包括心脏和血管。然而，昼夜节律系统比这种基本的层次结构更为复杂，这一发现表明，外围时钟要么受到一定程度的影响，要么完全受能量稳态的时间变化驱动，而与光的夹带途径无关。通过各种比较基因组方法以及通过利用小鼠遗传学和转基因学的研究，我们现在认识到心血管组织具有大量的代谢基因，其表达周期和相互影响主要生物钟基因的转录控制。这些发现表明，代谢周期可以直接或间接影响心血管功能的昼夜节律。在这里，我们讨论了一个框架，该框架用于理解整合心血管和代谢功能的昼夜节律系统如何驱动24小时血压节律。

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  • 来源
    《Endocrine journal》 |2012年第6期|p.447-456|共10页
  • 作者

    Akira Kohsaka; Hidefumi Waki; He Cui; Sabine S. Gouraud; Masanobu Maeda;

  • 作者单位

    Department of Physiology, Wakayama Medical University School of Medicine, 811-1 Kimiidera, Wakayama 641-8509, Japan;

    Department of Physiology, Wakayama Medical University School of Medicine, Wakayama 641-8509, Japan;

    Department of Physiology, Shandong Medical College, Shandong 250002, China;

    Department of Physiology, Wakayama Medical University School of Medicine, Wakayama 641-8509, Japan;

    Department of Physiology, Wakayama Medical University School of Medicine, Wakayama 641-8509, Japan;

  • 收录信息 美国《科学引文索引》(SCI);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    circadian clock; cardiovascular diurnal rhythm; metabolic cycle; blood pressure;

    机译：生物钟心血管昼夜节律代谢周期血压;

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