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首页> 外文期刊>Endocrine journal >First Japanese Patient Treated with Parathyroid Hormone Peptide Immunization for Refractory Hypercalcemia Caused by Metastatic Parathyroid Carcinoma
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First Japanese Patient Treated with Parathyroid Hormone Peptide Immunization for Refractory Hypercalcemia Caused by Metastatic Parathyroid Carcinoma

机译：日本首例接受甲状旁腺激素肽免疫治疗的转移性甲状旁腺癌引起的难治性高钙血症患者

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摘要

Patients with unresectable parathyroid carcinoma develop severe hypercalcemia, bone fractures and renal failure, and become unresponsive to conventional treatments. It has been shown that successful induction of anti-parathyroid hormone (PTH) antibodies, using PTH peptide fragments for immunisation, normalized serum levels of calcium as well as improved clinical symptoms. Here, we report our experience of PTH immunization in a Japanese female suffering from refractory hypercalcemia and renal failure caused by unresectable metastatic parathyroid carcinoma. Upon immunization, there were apparent clinical responses including reduction of serum levels of Ca along with anti-PTH antibodies induction. Therefore, we concluded that PTH immunization was an effective treatment against hypercalcemia caused by metastatic parathyroid carcinomas that are unresponsive to conventional treatments.
机译：不可切除的甲状旁腺癌患者会出现严重的高钙血症，骨折和肾功能衰竭，并对常规治疗无反应。已经显示，使用PTH肽片段进行免疫，血清钙水平正常化以及改善的临床症状，成功诱导了抗甲状旁腺激素（PTH）抗体。在这里，我们报告了日本女性因无法切除的转移性甲状旁腺癌引起的难治性高钙血症和肾功能衰竭的免疫接种经验。免疫后，出现明显的临床反应，包括降低血清钙水平以及诱导抗PTH抗体。因此，我们得出结论，PTH免疫是针对转移性甲状旁腺癌引起的高钙血症的有效治疗，而对传统治疗无反应。

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  • 来源
    《Endocrine journal》 |2010年第4期|P.287-292|共6页
  • 作者

    Ichiro HORIE; Takao ANDO; Naoko INOKUCHI; Yumi MIHARA; Shiro MIURA; Misa IMAIZUMI; Toshiro USA; Naoe KINOSHITA; Ichiro SEKINE; Shimeru KAMIHARA; Katsumi EGUCHI;

  • 作者单位

    First Department of Medicine, Nagasaki University School of Medicine, Nagasaki 852-8501, Japan;

    First Department of Medicine, Nagasaki University School of Medicine, Nagasaki 852-8501, Japan;

    Department of Laboratory Medicine, Nagasaki University School of Medicine, Nagasaki 852-8501, Japan;

    Division of Tumor and Diagnostic Pathology, Nagasaki University School of Medicine, Nagasaki 852-8501, Japan;

    Division of Tumor and Diagnostic Pathology, Nagasaki University School of Medicine, Nagasaki 852-8501, Japan;

    First Department of Medicine, Nagasaki University School of Medicine, Nagasaki 852-8501, Japan;

    First Department of Medicine, Nagasaki University School of Medicine, Nagasaki 852-8501, Japan;

    Department of Pathology, Nagasaki University School of Medicine, Nagasaki 852-8501, Japan;

    rnDivision of Tumor and Diagnostic Pathology, Nagasaki University School of Medicine, Nagasaki 852-8501, Japan;

    Department of Laboratory Medicine, Nagasaki University School of Medicine, Nagasaki 852-8501, Japan;

    First Department of Medicine, Nagasaki University School of Medicine, Nagasaki 852-8501, Japan;

  • 收录信息 美国《科学引文索引》(SCI);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    PTH; parathyroid; carcinoma; metastasis; immunization;

    机译：PTH;甲状旁腺癌;转移;免疫;

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