DNA sequence of the 5′ flanking region of the human interleukin 2 gene: homologies with adult T-cell leukemia virus

Gerald R. Crabtree; Michael Lieber; Nikki J. Holbrook

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DNA sequence of the 5′ flanking region of the human interleukin 2 gene: homologies with adult T-cell leukemia virus

机译：人白细胞介素2基因的5'侧翼区域的DNA序列：成人T细胞白血病病毒的同源性

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We previously reported the sequence of the gene for human interleukin 2 (IL-2) which included about 220 b.p. of the 5′ flanking region. In this report we have extended the 5′ sequence to 1263 b.p. before the start site of transcription and have compared the entire sequence of the IL-2 gene and its 5′ flanking region with that of Adult T-cell leukemia virus (ATLV). Four regions of limited homology were noted. Three areas of homology to the viral long terminal repeat (LTR) were seen in the 5′ sequence flanking IL-2. A fourth region of homology to the viral LTR was located within the second intron of the IL-2 gene. While the significance of these homologies is not known, it is possible that they are involved in regulating the expression of ATLV and IL-2, both of which are generally restricted to T cells.

机译：我们之前报道了包括约220 B.P的人白细胞介素2（IL-2）的基因序列。在5'侧翼区域。在本报告中，我们将5'序列扩展到1263 B.P.在转录开始之前并将其与成人T细胞白血病病毒（ATLV）的整个IL-2基因及其5'侧翼区域进行了比较。注意到有限的同源性的区域。在5'序列侧翼IL-2中可以看到对病毒长末端重复（LTR）的三个同源性的。对病毒LTR的第四个同源性地位于IL-2基因的第二内含子内。虽然这些同源性的重要性尚不清楚，但它们可以参与调节ATLV和IL-2的表达，这两者通常限于T细胞。

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《Nucleic acids research》 |1984年第12期|共9页
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Gerald R. Crabtree; Michael Lieber; Nikki J. Holbrook;
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1. DNA sequence of the 5′ flanking region of the human interleukin 2 gene: homologies with adult T-cell leukemia virus [J] . Gerald R. Crabtree, Michael Lieber, Nikki J. Holbrook Nucleic acids research . 1984,第12期

机译：人白细胞介素2基因的5'侧翼区域的DNA序列：成人T细胞白血病病毒的同源性
2. DNA sequence of the 5′ flanking region of the human interleukin 2 gene: homologies with adult T-cell leukemia virus [J] . Gerald R. Crabtree, Michael Lieber, Nikki J. Holbrook Nucleic acids research . 1984,第12期

机译：人白细胞介素2基因的5'侧翼区域的DNA序列：成人T细胞白血病病毒的同源性
3. Interleukin (IL) 15/IL-T production by the adult T-cell leukemia cell line HuT-102 is associated with a human T-cell lymphotrophic virus type I R region/IL-15 fusion message that lacks many upstream AUGs that normally attenuate IL-15 mRNA translation [J] . Richard N. Bamford, Andrew P. Battiata, Jack D. Burton Proceedings of the National Academy of Sciences of the United States of America . 1996,第7期

机译：成年T细胞白血病细胞系HuT-102产生白介素（IL）15 / IL-T与人类T细胞淋巴营养型IR区/ IL-15融合信息有关，该信息缺乏通常能减弱IL的许多上游AUG -15 mRNA翻译
4. Characterization of cancer specific human monoclonal IgM antibodies produced by hybridomas derived from a patient with adult T-cell leukemia [C] . T. KAWAHARA, A. ICHIKAWA, Y. KATAKURA, Annual Meeting of the Japanese Association for Animal Cell Technology . 2002

机译：杂交瘤产生的癌症特异性人单克隆IgM抗体的表征衍生自成人T细胞白血病患者的杂交瘤
5. Isolation and functional mapping of Human T-cell Leukemia Virus Type 1 Tax oncoprotein DNA-damage complexes. [D] . Durkin, Sarah Saionz. 2006

机译：人类T细胞白血病病毒1型税收癌蛋白DNA损伤复合物的分离和功能定位。
6. DNA sequence of the 5 flanking region of the human interleukin 2 gene: homologies with adult T-cell leukemia virus. [O] . N J Holbrook, M Lieber, G R Crabtree 1984

机译：人白介素2基因5侧翼区的DNA序列：与成人T细胞白血病病毒的同源性。
7. DNA sequence of the 5' flanking region of the human interleukin 2 gene: homologies with adult T-cell leukemia virus. [O] . Holbrook, N J, Lieber, M, Crabtree, G R 1984

机译：人白介素2基因5'侧翼区的DNA序列：与成人T细胞白血病病毒的同源性。
8. Leukemias Associated with Human T-Cell Lymphotropic Virus Type I in a Non-Endemic Region. (Reannouncement with New Availability Information). [R] . Ratner, L., Poiesz, B. J. 1988

机译：白血病与非地方区域的人类T细胞淋巴细胞病毒I型相关。（重新公布新的可用性信息）。

DNA sequence of the 5′ flanking region of the human interleukin 2 gene: homologies with adult T-cell leukemia virus

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