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首页> 外文期刊>Journal of Clinical Microbiology >Association with phagocytic inhibition of anti-Pseudomonas aeruginosa immunoglobulin G antibody subclass levels in serum from patients with cystic fibrosis.
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Association with phagocytic inhibition of anti-Pseudomonas aeruginosa immunoglobulin G antibody subclass levels in serum from patients with cystic fibrosis.

机译：与囊性纤维化患者血清血清中抗假鼠铜绿素抑制的抗假鼠铜绿素抑制的关系。

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摘要

Serum from cystic fibrosis patients colonized with Pseudomonas aeruginosa specifically inhibits phagocytosis of P. aeruginosa by alveolar macrophages. Serum was examined for P. aeruginosa lipopolysaccharide-specific immunoglobulin G (IgG) subclass levels (by enzyme-linked immunosorbent assay) and for the effect on macrophage phagocytosis (by radiolabeled P. aeruginosa uptake). Sera from cystic fibrosis patients with no known P. aeruginosa colonization history had negligible amounts of lipopolysaccharide-specific IgG and a mean phagocytic enhancement of 5%. The sera of normal volunteers also had negligible amounts of lipopolysaccharide-specific IgG. Serum from cystic fibrosis patients with P. aeruginosa respiratory tract infections had substantial titers (range, 1:20 to 1:1,280) of lipopolysaccharide-specific IgG2, IgG3, and IgG4 and a mean phagocytic inhibition of 56%. However, these patients had low or absent titers of lipopolysaccharide-specific IgG1. No consistent variation in the level of individual IgG subclasses in the sera of colonized patients was observed, as determined by radial immunodiffusion. The results suggest that during P. aeruginosa infection phagocytosis-inhibitory activity develops coincident with production of lipopolysaccharide-specific IgG subclasses.
机译：来自囊性纤维化患者的血清与假单胞菌铜绿假单胞菌殖民特异性抑制了肺泡巨噬细胞P.铜绿假单胞菌的吞噬作用。针对铜绿假单胞菌脂多糖特异性免疫球蛋白G（IgG）亚类水平（通过酶联免疫吸附试验）检测血清，并对巨噬细胞吞噬作用的影响（通过放射性标记的P. Arginosa吸收）。来自囊性纤维化患者的血清没有已知的P.铜绿假单胞菌殖民化历史具有可忽略量的脂多糖特异性IgG和平均吞噬增强5％的吞噬细胞增强。正常志愿者的血清也具有可忽略量的脂多糖特异性IgG。来自囊性纤维化患者P.铜绿假症呼吸道感染的血清具有大量滴度（范围，1:20至1：1,280），脂多糖特异性IgG2，IgG3和IgG4，平均吞噬抑制为56％。然而，这些患者具有脂多糖特异性IgG1的低或不存在滴度。观察到由径向免疫分子确定的殖民化患者血清中单个IgG亚类水平的一致变异。结果表明，在P.铜绿假单胞菌感染吞噬作用症抑制活性与脂多糖特异性IgG亚类的生产一致。

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