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首页> 外文期刊>Journal of Virology >Natural killer cell suppression of Friend virus-induced preleukemic hemopoietic stem cells.
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Natural killer cell suppression of Friend virus-induced preleukemic hemopoietic stem cells.

机译：自然杀伤细胞抑制朋友病毒诱导的预血管血液吞血干细胞。

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摘要

To determine whether hemopoietic cells infected with Friend polycythemia-inducing spleen focus-forming virus (SFFVp) are conserved or suppressed via natural surveillance in leukemia-resistant adult mice, we engrafted C57BL/6 recipients with isologous transgenic (donor origin marker) or natural killer (NK) cell-deficient B6 beige marrow cells exposed to SFFVp in vitro. Both groups of primary recipients were viremic and nonleukemic. Spleen cells from primary SFFVp-infected chimeras were engrafted into irradiated leukemia-susceptible secondary recipients to reveal dormant leukemia and grew as tumors of donor origin in 8 of 38 (21%) and 33 of 47 (70%) instances, respectively. Treatment of marrow donors and recipients with anti-asialo GM1 serum resulted in the depression of NK cell activity and the rapid development of dormant leukemia. We conclude that NK cells are an effective surveillance mechanism able to suppress SFFVp-induced preleukemic stem cells.
机译：为了确定是否通过白血病成年小鼠的天然监测，通过天然监测来确定感染的血细胞病诱导脾脏聚焦形成病毒（SFFVP）是否受到保守或抑制，我们将C57BL / 6受者植入了具有雌性转基因（供体来源标记物）或天然杀伤者（NK）细胞缺陷的B6米色骨髓细胞在体外暴露于SFFVP。两组初级受者都是雌雄激烈和非血症。将来自原发性SFFVP感染的嵌合体的脾细胞植入着辐照的白血病易受次要受者，以揭示休眠白血病，并随着供体源的肿瘤的88（21％）和33个（70％）实例中的33个（70％）。用抗ASIALOGM1血清治疗骨髓供体和受体导致NK细胞活性的抑郁和休眠白血病的快速发展。我们得出结论，NK细胞是一种能够抑制SFFVP诱导的前血管血糖干细胞的有效监测机制。

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