首页> 外国专利> Methods for producing dendritic cells that stimulate natural killer T (NKT) cells, methods for producing dendritic cells that stimulate NKT cells, methods for producing cell compositions containing dendritic cells that stimulate NKT cells and NKT cells, and NKT cells. Cell composition containing stimulating dendritic cells and NKT cells

Methods for producing dendritic cells that stimulate natural killer T (NKT) cells, methods for producing dendritic cells that stimulate NKT cells, methods for producing cell compositions containing dendritic cells that stimulate NKT cells and NKT cells, and NKT cells. Cell composition containing stimulating dendritic cells and NKT cells

机译：制备刺激天然杀伤T（NKT）细胞的树突细胞的方法，制备刺激NKT细胞的树突细胞的方法，制备含有刺激NKT细胞和NKT细胞的树突细胞的细胞组合物和NKT细胞的方法。含有刺激树突细胞和NKT细胞的细胞组合物

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摘要

Provided is a method for manufacturing NKT-cell stimulating dendritic cells, the method including: a step for placing mononuclear cells in a culturing vessel and allowing some of the mononuclear cells to settle on a bottom surface of the vessel by keeping the culture still; a step for removing floating cells other than the cells that have settled on the bottom surface of the culturing vessel; a step for causing monocytes among the cells that have settled on the bottom surface to differentiate into immature dendritic cells by adding a predetermined factor to the culturing vessel; and a step for inducing mature dendritic cells into NKT-cell stimulating dendritic cells by adding α-galactosylceramide to the culturing vessel.

机译：提供了一种制备NKT细胞刺激树突细胞的方法，该方法包括：通过保持培养物静止仍然将一些单核细胞置于培养容器中并允许一些单核细胞在容器的底表面上沉淀的步骤;除了在培养容器的底表面上沉积的细胞以外的浮动细胞去除浮动细胞的步骤;通过向培养容器中加入预定因子，使在底表面上沉淀到底表面上的细胞中的单核细胞的步骤;并且通过将α-半乳糖基胺加入培养容器中，将成熟树突细胞诱导成熟树突细胞进入NKT细胞刺激树突细胞的步骤。

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公开/公告号JP6854290B2

专利类型
公开/公告日2021-04-07

原文格式PDF
申请/专利权人株式会社理研免疫再生医学;
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申请/专利号JP20180537405
发明设计人野口活夫;只木敏雅;
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申请日2017-08-31
分类号C12N5/0784;C12N5/0783;
国家 JP
入库时间 2022-08-24 18:07:53

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