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A viral envelope as a vehicle for tracer, drug, and gene delivery

机译:病毒包膜作为示踪剂,药物和基因递送的载体

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摘要

Gene and drug encapsulation by a viral vector administered via a systemic injection represents a therapeutic delivery system that is noninvasive and can potentially be targeted to a region of the body. However, an effective way of monitoring biodistribution, both acutely and over the long term, is needed to evaluate new targeting technologies and to tailor patient care in the clinic. A sensitive and dynamic method is needed to compare the effect of various approaches on clearance. Positron emission tomography (PET) imaging can detect radiotracers within the body with high sensitivity, and, in this study, the noninvasive tracking of viral vectors tagged with radioactive fluorine ([F-18]fluoride) is presented.
机译:通过经由全身注射施用的病毒载体进行的基因和药物包封代表了一种治疗性递送系统,该系统是非侵入性的并且可以潜在地靶向人体区域。但是,需要一种有效的方法来急性和长期地监测生物分布,以评估新的靶向技术并在临床中调整患者护理水平。需要一种灵敏而动态的方法来比较各种方法对间隙的影响。正电子发射断层扫描(PET)成像可以高灵敏度地检测体内的放射性示踪剂,在这项研究中,提出了用放射性氟([F-18]氟化物)标记的病毒载体的无创跟踪。

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