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首页> 外文期刊>Environment international >Fish intake and breastfeeding time are associated with serum concentrations of organochlorines in a Swedish population
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Fish intake and breastfeeding time are associated with serum concentrations of organochlorines in a Swedish population

机译：鱼的摄入量和母乳喂养时间与瑞典人群中有机氯的血清浓度有关

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摘要

Persistent organic pollutants (POPs) exert harmful effects on cognitive, endocrine and immune functions and bioaccumulate in the environment and human tissues. The aim of this study was to investigate the body burden of several POPs in the adult population (n=246) and their association to diet and other lifestyle factors in a Swedish national survey. Serum concentrations of several polychlorinated biphenyls (PCBs), and the pesticides hexachlorobenzene (HCB), p-hexachlorocydohexane (β-HCH), chlordane compounds and dichlorodiphenyldichloroethylene (DDE) were determined by liquid-liquid extraction, silica column cleanup and gas chromatography high resolution mass spectrometry. Diet was assessed using 4-day food records and complementary dietary and lifestyle factors by questionnaire. Fish intake was additionally assessed by plasma fatty acid composition. Clustering of the compounds revealed that PCBs were separated into two clusters, one including low-chlorinated PCB 28 and 52, and the other high-chlorinated mono- and di-ortho PCBs, suggesting similarities and dissimilarities in exposure sources and possibly also toxicokinetics. Men had 24% and 32% higher levels of PCB 138-180 and chlordane compounds, respectively, compared with women. This may partly be explained by elimination of the POPs among women reporting a history of breastfeeding. The proportion of very long-chain n-3 fatty acids in plasma were positively correlated with the pollutants: r=0.24 (PCB 28), r= 0.33 (PCB 118), r = 0.35 (PCB 138-180), r = 0.29 (HCB), r=0.18 (β-HCH), r = 0.34 (chlordane compounds), r = 0.34 (p,p'-DDE), p≤0.005. Individuals consuming fatty Baltic fish≥1 time per months had 45% higher serum levels of PCB 118 compared with non-consumers. Levels of PCB 28 were associated with the age of the residential building. To conclude, the population-distributed approach of surveying dietary habits, lifestyle factors and POP body burdens, made it possible to identify personal characteristics associated with the POP body burdens in Sweden.
机译：持久性有机污染物（POPs）对认知，内分泌和免疫功能产生有害影响，并在环境和人体组织中发生生物蓄积。这项研究的目的是在瑞典的一项全国性调查中调查成年人群（n = 246）中几种持久性有机污染物的身体负担及其与饮食和其他生活方式因素的关系。通过液-液萃取，硅胶柱净化和气相色谱高分辨率方法测定了几种多氯联苯（PCBs）和农药六氯苯（HCB），对六氯环己烷（β-HCH），氯丹化合物和二氯二苯基二氯乙烯（DDE）的血清浓度质谱。使用4天食物记录和补充饮食和生活方式因素通过问卷评估饮食。还通过血浆脂肪酸组成评估鱼的摄入量。化合物的聚类表明，PCB被分为两个簇，一个簇包括低氯化的PCB 28和52，另一个簇是高氯化的单和双邻位PCB，这表明暴露源以及毒物动力学之间存在相似性和相异性。与女性相比，男性的PCB 138-180和氯丹化合物含量分别高24％和32％。部分原因是在报告有母乳喂养史的妇女中消除了持久性有机污染物。血浆中长链n-3脂肪酸的比例与污染物呈正相关：r = 0.24（PCB 28），r = 0.33（PCB 118），r = 0.35（PCB 138-180），r = 0.29 （HCB），r ＝ 0.18（β-HCH），r ＝ 0.34（氯丹化合物），r ＝ 0.34（p，p′-DDE），p≤0.005。每月食用≥1次脂肪波罗的海鱼类的人血清PCB 118含量比非食用者高45％。 PCB 28的水平与住宅的使用年限相关。总之，调查饮食习惯，生活方式因素和持久性有机污染物的身体负担的人口分布方法使在瑞典确定与持久性有机污染物的身体负担相关的个人特征成为可能。

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  • 来源
    《Environment international》 |2013年第1期|88-96|共9页
  • 作者

    Helena Bjermo; Per Ola Darnerud; Sanna Lignell; Monika Pearson; Panu Rantakokko; Cecilia Naelsen; Helene Enghardt Barbieri; Hannu Kiviranta; Anna Karin Lindroos; Anders Glynn;

  • 作者单位

    National Food Agency, P.O. Box 622, SE-751 26 Uppsala, Sweden;

    National Food Agency, P.O. Box 622, SE-751 26 Uppsala, Sweden;

    National Food Agency, P.O. Box 622, SE-751 26 Uppsala, Sweden;

    National Food Agency, P.O. Box 622, SE-751 26 Uppsala, Sweden;

    National Institute for Health and Welfare (THL), P.O. Box 95, FI-707 01 Kuopio, Finland;

    National Food Agency, P.O. Box 622, SE-751 26 Uppsala, Sweden;

    National Food Agency, P.O. Box 622, SE-751 26 Uppsala, Sweden;

    National Institute for Health and Welfare (THL), P.O. Box 95, FI-707 01 Kuopio, Finland;

    National Food Agency, P.O. Box 622, SE-751 26 Uppsala, Sweden;

    National Food Agency, P.O. Box 622, SE-751 26 Uppsala, Sweden;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    PCB; chlordane; HCB; β-HCH; baltic sea fish; breastfeeding;

    机译：PCB;氯丹六氯苯乙型六氯环己烷;波罗的海鱼;哺乳;

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