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Ambient air pollution exposure and risk of migraine: Synergistic effect with high temperature

机译:暴露于环境空气污染和偏头痛的风险:与高温的协同效应

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摘要

Background: Migraine is a chronic and agonizing neurological disorder prevalent worldwide. Although its pathogenesis remains unclear, limited evidence exists on the role of air pollution.Objective: We aimed to assess the association of short-term air pollution exposure with migraine in conjunction with the synergistic effect of temperature.Methods: We identified 18,921 patients who visited emergency departments (EDs) for migraine as a primary disease in Seoul from the national emergency database between 2008 and 2014. We conducted a time -stratified, case-crossover analysis to compare levels of particles 2.5 mu m (PM2.5), particles 10 mu m (PM10), nitrogen dioxide (NO2), sulfur dioxide (SO2), ozone (O-3), and carbon monoxide (CO) on ED visit days and those on the control days matched to day of the week, month, and year. We evaluated the synergistic effects of air pollution and temperature using an interaction term.Results: Higher air pollution levels were significantly associated with risk of migraine over various lag structures. In the best fitting lags, the odds ratio (OR) associated with an interquartile range increase of PM2.5, PM10, NO2, O-3, and CO was 1.031 (95% CI: 1.010-1.053), 1.032 (95% CI: 1.007-1.057), 1.053 (95% CI: 1.022-1.085), 1.034 (95% CI: 1.001-1.067), and 1.029 (95% CI: 1.005-1.053), respectively. The SO2 effect was positive but not significant (OR 1.019 [95% CI: 0.991-1.047]). The PM effect was significantly stronger on high-temperature days (above the 75th percentile) than on low-temperature days (PM2.5, high: OR 1.068, low: OR 1.021, P-interact= 0.03; PM10, high: OR 1.066, low: OR 1.014, P-interact = 0.02).Conclusion: Our study provides new evidence that air pollution exposure may trigger migraine especially on high-temperature days, and this finding may contribute in establishing preventive measures against migraine.
机译:背景:偏头痛是世界范围内普遍存在的一种慢性激动性神经疾病。尽管尚不清楚其发病机理,但关于空气污染的作用的证据有限。目的:我们旨在评估短期空气污染暴露与偏头痛以及温度的协同作用之间的关系。方法:我们确定了18,921名患者国家急诊数据库在2008年至2014年之间将首尔偏头痛作为主要疾病的急诊科(ED)。我们进行了时间分层的病例交叉分析,比较了<2.5微米(PM2.5),在ED拜访日和对照日与星期几相匹配的时间中,<10微米(PM10),二氧化氮(NO2),二氧化硫(SO2),臭氧(O-3)和一氧化碳(CO),月份和年份。我们使用一个相互作用项评估了空气污染和温度的协同效应。结果:在不同的滞后结构中,较高的空气污染水平与偏头痛风险显着相关。在最佳拟合滞后中,与PM2.5,PM10,NO2,O-3和CO的四分位数间距增加相关的优势比(OR)为1.031(95%CI:1.010-1.053),1.032(95%CI) :1.007-1.057),1.053(95%CI:1.022-1.085),1.034(95%CI:1.001-1.067)和1.029(95%CI:1.005-1.053)。 SO2效应为阳性但不显着(OR 1.019 [95%CI:0.991-1.047])。在高温天(高于第75个百分位数)时,PM效果显着强于低温天(PM2.5,高:OR 1.068,低:OR 1.021,P-interact = 0.03; PM10,高:OR 1.066 ,低:OR 1.014,P-interact = 0.02)。结论:我们的研究提供了新的证据,表明空气污染暴露可能会引发偏头痛,尤其是在高温天,这一发现可能有助于建立预防偏头痛的措施。

著录项

  • 来源
    《Environment international》 |2018年第1期|383-391|共9页
  • 作者单位

    Sungkyunkwan Univ, Sch Med, Dept Social & Prevent Med, Suwon, Gyeonggi Do, South Korea;

    Seoul Natl Univ, Grad Sch Publ Hlth, Dept Publ Hlth Sci, Seoul, South Korea;

    Seoul Natl Univ, Inst Hlth & Environm, Seoul, South Korea;

    Seoul Natl Univ, Grad Sch Publ Hlth, Dept Air Pollut & Climate Change, Seoul, South Korea;

    Seoul Natl Univ, Grad Sch Publ Hlth, Dept Chron Dis Epidemiol, Seoul, South Korea;

    Seoul Natl Univ, Bundang Hosp, Pain Ctr, Dept Neuropsychiat, 29,Gumi Ro 173Beon Gil, Seongnam Si 13619, Gyeonggi Do, South Korea;

    Seoul Natl Univ, Dept Prevent Med, Coll Med, Seoul, South Korea;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Air pollution; Migraine; Temperature; Effect modification; Case-crossover analysis;

    机译:空气污染;偏头痛;温度;效应修正;事例交叉分析;

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