• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Environment international >Association between bisphenol a exposure and idiopathic central precocious puberty (ICPP) among school-aged girls in Shanghai, China
【24h】

Association between bisphenol a exposure and idiopathic central precocious puberty (ICPP) among school-aged girls in Shanghai, China

机译：中国上海学龄女孩中双酚A暴露与特发性中枢性早熟（ICPP）之间的关联

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background: Bisphenol A (BPA) is a well-known and widely used endocrine disrupter, but data on its association with childhood reproductive development are limited.Objectives: We investigated the possible relationship between exposure to BPA and idiopathic central precocious puberty (ICPP) in school-aged girls.Methods: We conducted a 1: 1 matched case-control study in Shanghai, China, between July 2011 and September 2012. This study included 136 school-aged (6 to 9 years old) girls diagnosed with ICPP and 136 controls matched for age and body mass index (BMI). We measured the urinary BPA concentrations of all the girls and examined the association with odds of having ICPP. Laboratory examinations including serum estradiol (E2) levels, basal and gonadotropin-releasing hormone (GnRH)-stimulated luteinizing hormone (LH), and follicle-stimulating hormone (FSH) levels, bone ages (BA), and uterine and ovarian sizes were conducted in the ICPP girls.Results: Median concentrations of urinary BPA in the ICPP and control groups were 6.35 and 1.17 mu g/g creatinine (Cr), respectively (p 0.001). After adjustment for confounders, compared to those with the lowest concentrations of BPA, the highest concentrations were associated with a 9.08-fold increased odds of having ICPP [odds ratio (OR)= 9.08, (95% confidence interval (CI): 2.83-29.15)]. In the ICPP group, modest negative correlation was present between urinary BPA concentrations (mu g/g Cr) and peak FSH levels [beta=-0.090 (95% CI: -0.178, -0.003), p = 0.044].Conclusions: Our findings suggest that BPA exposure is associated with increased odds of having ICPP in schoolaged girls, and the potential mechanism may be attributable to the relatively low FSH levels.
机译：背景：双酚A（BPA）是一种广为人知的广泛使用的内分泌干扰物，但有关其与儿童生殖发育的关联的数据十分有限。目的：我们调查了BPA暴露与特发性中枢性性早熟（ICPP）之间的可能关系。方法：2011年7月至2012年9月，我们在中国上海进行了1：1配对病例对照研究。该研究包括136名被诊断为ICPP的学龄（6至9岁）女孩和136名。与年龄和体重指数（BMI）相匹配的对照。我们测量了所有女孩的尿液中BPA的浓度，并检查了患ICPP的可能性。进行了实验室检查，包括血清雌二醇（E2）水平，基础和促性腺激素释放激素（GnRH）刺激的促黄体生成激素（LH）和促卵泡激素（FSH）水平，骨龄（BA）以及子宫和卵巢大小结果：ICPP组和对照组的尿液BPA中位数浓度分别为6.35和1.17μg / g肌酐（Cr）（p <0.001）。调整混杂因素后，与最低BPA浓度的混杂物相比，最高浓度与ICPP的几率增加了9.08倍[几率（OR）= 9.08，（95％置信区间（CI）：2.83- 29.15）]。在ICPP组中，尿中BPA浓度（μg / g Cr）与FSH峰值之间存在中等程度的负相关[β= -0.090（95％CI：-0.178，-0.003），p = 0.044]。研究结果表明，双酚A暴露与学龄女孩患ICPP的几率增加有关，其潜在机制可能归因于FSH水平较低。

著录项

  • 来源
    《Environment international》 |2018年第6期|410-416|共7页
  • 作者

    Chen Yao; Wang Yingcan; Ding Guodong; Tian Ying; Zhou Zhijun; Wang Xiumin; Shen Lixiao; Huang Hong;

  • 作者单位

    Shanghai Jiao Tong Univ, Sch Med, Xinhua Hosp, MOE, 1665 Kongjiang Rd, Shanghai 200092, Peoples R China|Shanghai Jiao Tong Univ, Sch Med, Xinhua Hosp, Shanghai Key Lab Childrens Environm Hlth, 1665 Kongjiang Rd, Shanghai 200092, Peoples R China|Shanghai Jiao Tong Univ, Sch Med, Shanghai Childrens Med Ctr, Dept Endocrinol & Genet Dis, Shanghai, Peoples R China;

    Shanghai Jiao Tong Univ, Sch Med, Xinhua Hosp, MOE, 1665 Kongjiang Rd, Shanghai 200092, Peoples R China|Shanghai Jiao Tong Univ, Sch Med, Xinhua Hosp, Shanghai Key Lab Childrens Environm Hlth, 1665 Kongjiang Rd, Shanghai 200092, Peoples R China|Shanghai Jiao Tong Univ, Sch Med, Xin Hua Hosp, Dept Neonatol, Shanghai, Peoples R China;

    Shanghai Jiao Tong Univ, Sch Med, Xinhua Hosp, MOE, 1665 Kongjiang Rd, Shanghai 200092, Peoples R China|Shanghai Jiao Tong Univ, Sch Med, Xinhua Hosp, Shanghai Key Lab Childrens Environm Hlth, 1665 Kongjiang Rd, Shanghai 200092, Peoples R China|Tongji Univ, Sch Med, Shanghai East Hosp, Dept Pediat, Shanghai, Peoples R China;

    Shanghai Jiao Tong Univ, Sch Med, Xinhua Hosp, MOE, 1665 Kongjiang Rd, Shanghai 200092, Peoples R China|Shanghai Jiao Tong Univ, Sch Med, Xinhua Hosp, Shanghai Key Lab Childrens Environm Hlth, 1665 Kongjiang Rd, Shanghai 200092, Peoples R China|Shanghai Jiao Tong Univ, Sch Med, Sch Publ Hlth, Dept Environm Hlth, Shanghai, Peoples R China;

    Fudan Univ, MOE Key Lab Publ Hlth Safety, Sch Publ Hlth, Shanghai, Peoples R China;

    Shanghai Jiao Tong Univ, Sch Med, Shanghai Childrens Med Ctr, Dept Endocrinol & Genet Dis, Shanghai, Peoples R China;

    Shanghai Jiao Tong Univ, Sch Med, Xin Hua Hosp, Dept Children Hlth Care, 1665 Kongjiang Rd, Shanghai 200092, Peoples R China;

    Shanghai Jiao Tong Univ, Sch Med, Xinhua Hosp, MOE, 1665 Kongjiang Rd, Shanghai 200092, Peoples R China|Shanghai Jiao Tong Univ, Sch Med, Xinhua Hosp, Shanghai Key Lab Childrens Environm Hlth, 1665 Kongjiang Rd, Shanghai 200092, Peoples R China|Shanghai Jiao Tong Univ, Sch Med, Sch Publ Hlth, Dept Environm Hlth, Shanghai, Peoples R China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Bisphenol A; Idiopathic central precocious puberty; Urine; Girl; China;

    机译：双酚A;特发性中枢性早熟;尿;女孩;中国;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号