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首页> 外文期刊>Environment international >Identification of chemical mixtures to which Canadian pregnant women are exposed: The MIREC Study
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Identification of chemical mixtures to which Canadian pregnant women are exposed: The MIREC Study

机译：鉴定加拿大孕妇所接触的化学混合物：MIREC研究

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摘要

Depending on the chemical and the outcome, prenatal exposures to environmental chemicals can lead to adverse effects on the pregnancy and child development, especially if exposure occurs during early gestation. Instead of focusing on prenatal exposure to individual chemicals, more studies have taken into account that humans are exposed to multiple environmental chemicals on a daily basis. The objectives of this analysis were to identify the pattern of chemical mixtures to which women are exposed and to characterize women with elevated exposures to various mixtures. Statistical techniques were applied to 28 chemicals measured simultaneously in the first trimester and socio-demographic factors of 1744 participants from the Maternal-Infant Research on Environment Chemicals (MIREC) Study. Cluster analysis was implemented to categorize participants based on their socio-demographic characteristics, while principal component analysis (PCA) was used to extract the chemicals with similar patterns and to reduce the dimension of the dataset. Next, hypothesis testing determined if the mean converted concentrations of chemical substances differed significantly among women with different socio-demographic backgrounds as well as among clusters. Cluster analysis identified six main socio-demographic clusters. Eleven components, which explained approximately 70% of the variance in the data, were retained in the PCA. Persistent organic pollutants (PCB118, PCB138, PCB153, PCB180, OXYCHLOR and TRANSNONA) and phthalates (MEOHP, MEHHP and MEHP) dominated the first and second Components, respectively, and the first two components explained 25.8% of the source variation. Prenatal exposure to persistent organic pollutants (first component) were positively associated with women who have lower education or higher income, were born in Canada, have BMI >= 25, or were expecting their first child in our study population. MEOHP, MEHHP and MEHP, dominating the second component, were detected in at least 98% of 1744 participants in our cohort study; however, no particular group of pregnant women was identified to be highly exposed to phthalates. While widely recognized as important to studying potential health effects, identifying the mixture of chemicals to which various segments of the population are exposed has been problematic. We present an approach using factor analysis through principal component method and cluster analysis as an attempt to determine the pregnancy exposome. Future studies should focus on how to include these matrices in examining the health effects of prenatal exposure to chemical mixtures in pregnant women and their children. Crown Copyright (C) 2016 Published by Elsevier Ltd.
机译：取决于化学物质和结果，产前暴露于环境化学物质可能会对怀孕和儿童发育产生不利影响，尤其是如果在妊娠早期发生暴露。与其专注于产前暴露于各种化学物质，不如研究更多的是人类每天都暴露于多种环境化学物质。这项分析的目的是确定女性所接触的化学混合物的模式，并表征暴露于各种混合物中的妇女的比例较高。统计技术应用于孕早期同时测量的28种化学药品以及来自母婴环境化学研究（MIREC）研究的1744名参与者的社会人口统计学因素。实施聚类分析以根据参与者的社会人口统计学特征对其进行分类，而主成分分析（PCA）用于提取具有相似模式的化学物质并缩小数据集的维数。接下来，假设检验确定了具有不同社会人口统计学背景的女性之间以及群体之间化学物质的平均转化浓度是否存在显着差异。聚类分析确定了六个主要的社会人口学聚类。 PCA中保留了11个成分，这些成分解释了数据中大约70％的差异。持久性有机污染物（PCB118，PCB138，PCB153，PCB180，OXYCHLOR和TRANSNONA）和邻苯二甲酸盐（MEOHP，MEHHP和MEHP）分别占第一和第二成分，前两个成分解释了25.8％的源变化。产前暴露于持久性有机污染物（第一成分）与受教育程度较低或收入较高，出生于加拿大，BMI> = 25或正在研究的第一个孩子的妇女呈正相关。在我们的队列研究中，至少有98％的1744名参与者检测到了MEOHP，MEHHP和MEHP（占第二位）。但是，没有特定的孕妇群体被发现与邻苯二甲酸盐高度接触。尽管被广泛认为对研究潜在的健康影响很重要，但要确定人群中各个阶层所接触的化学物质的混合物仍然存在问题。我们提出一种通过主成分法和聚类分析进行因子分析的方法，以尝试确定妊娠暴露体。未来的研究应集中在如何将这些基质包括在孕妇及其子女的产前暴露于化学混合物中对健康的影响上。 Crown版权所有（C）2016，由Elsevier Ltd.发布。

著录项

  • 来源
    《Environment international》 |2017年第2期|321-330|共10页
  • 作者

    Lee Wan-Chen; Fisher Mandy; Davis Karelyn; Arbuckle Tye E.; Sinha Sanjoy K.;

  • 作者单位

    Hlth Canada, Environm Hlth Sci & Res Bur, Ottawa, ON, Canada;

    Hlth Canada, Environm Hlth Sci & Res Bur, Ottawa, ON, Canada;

    Hlth Canada, Environm Hlth Sci & Res Bur, Ottawa, ON, Canada;

    Hlth Canada, Environm Hlth Sci & Res Bur, Ottawa, ON, Canada;

    Carleton Univ, Sch Math & Stat, Ottawa, ON, Canada;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Chemicals; Pregnancy; Mixtures;

    机译：化学品;怀孕;混合物;

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