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首页> 外文期刊>Environment international >Environmental exposure to lithium during pregnancy and fetal size: A longitudinal study in the Argentinean Andes
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Environmental exposure to lithium during pregnancy and fetal size: A longitudinal study in the Argentinean Andes

机译：怀孕和胎儿大小期间锂的环境暴露：阿根廷安第斯山脉的一项纵向研究

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摘要

Background: Lithium, used for treating bipolar disease, crosses freely the placenta and is classified as teratogenic. It is unclear to what extent environmental lithium exposure may affect fetal growth and development. Objectives: To elucidate potential effects of lithium exposure through drinking water during pregnancy on fetal size. Methods: We developed a prospective population-based mother-child cohort (N = 194) in an area with highly varying drinking water lithium concentrations (5-1600 pg/L) in northern Argentinean Andes. Blood and urinary lithium concentrations (sampled repeatedly during pregnancy) were measured using inductively coupled plasma mass spectrometry. We measured fetal size by ultrasound in second and third trimesters, and weight, length and head circumference at birth. Multivariable models were used to examine associations between lithium exposure (continuous and in tertiles) and fetal size measures. Results: Lithium in maternal blood (median 25; range 1.9-145 pg/L) and urine (1645; 105-4600 pg/L) was inversely associated (apparently linearly) with all fetal measures (body, head and femur) in the second trimester, and with birth length (fI, 0.53 cm per 25 pg/L increase in blood lithium, 95%Cl 1.0; 0.052). An increase of 100 pg/L in blood was associated with 2 cm shorter newborns (about one standard deviation). Conclusions: Lithium exposure through drinking water was associated with impaired fetal size and this seemed to be initiated in early gestation. Further studies are warranted to confirm causality and to understand the mechanisms. If confirmed, these findings have public health relevance and emphasize the need for more data on lithium concentrations in drinldng water, including bottled water. 2015 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecornmons.org/licenses/by-nc-nd/4.0/).
机译：背景：用于治疗躁郁症的锂可自由穿过胎盘，被归类为致畸物。目前尚不清楚环境中锂的暴露可能在多大程度上影响胎儿的生长发育。目的：阐明怀孕期间通过饮用水摄入锂对胎儿大小的潜在影响。方法：我们在阿根廷安第斯山脉北部饮用水锂浓度（5-1600 pg / L）变化很大的地区建立了一个以人口为基础的前瞻性人群（N = 194）。使用感应耦合等离子体质谱法测量血液和尿中锂的浓度（在怀孕期间重复采样）。我们在中，晚期通过超声测量了胎儿的大小，并在出生时测量了体重，长度和头围。多变量模型用于检验锂暴露（连续和三分位数）与胎儿体型测量之间的关联。结果：孕妇血液中的锂（中位数25；范围1.9-145 pg / L）和尿液中的锂（1645； 105-4600 pg / L）与胎儿中的所有胎儿测量指标（身体，头部和股骨）呈负相关（显然呈线性关系）。孕中期和出生时长（血液中锂离子浓度每25 pg / L升高0.53 cm，95％Cl 1.0; 0.052）。血液中100 pg / L的升高与2 cm较短的新生儿（约一个标准偏差）有关。结论：饮用水中锂的暴露与胎儿大小受损有关，这似乎是在妊娠早期开始的。有必要进行进一步的研究以确认因果关系并了解其机制。如果得到证实，则这些发现与公共卫生有关，并强调需要更多有关饮用水（包括瓶装水）中锂浓度的数据。 2015作者。由Elsevier Ltd.发布。这是CC BY-NC-ND许可下的开放获取文章（http://creativecornmons.org/licenses/by-nc-nd/4.0/）。

著录项

  • 来源
    《Environment international》 |2015年第4期|48-54|共7页
  • 作者

    Harari Florencia; Langeen Margareta; Casimiro Esperanza; Bottai Matteo; Palm Brita; Nordqvist Helena; Vahter Marie;

  • 作者单位

    Karolinska Inst, Inst Environm Med, Unit Met & Hlth, S-17177 Stockholm, Sweden;

    Karolinska Inst, Inst Environm Med, Unit Met & Hlth, S-17177 Stockholm, Sweden;

    Hosp Dr Nicolas Cayetano Pagano, Area Operat 29, Supervisor Intermedio Atenc Primaria Salud, RA-4411 San Antonio De Los Cobre, Salta, Argentina;

    Karolinska Inst, Inst Environm Med, Biostat Unit, S-17177 Stockholm, Sweden;

    Karolinska Inst, Inst Environm Med, Unit Met & Hlth, S-17177 Stockholm, Sweden;

    Karolinska Inst, Inst Environm Med, Unit Met & Hlth, S-17177 Stockholm, Sweden;

    Karolinska Inst, Inst Environm Med, Unit Met & Hlth, S-17177 Stockholm, Sweden;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Birth weight; Fetal size; Early-life exposure; Lithium; Water pollutants;

    机译：出生体重;胎儿大小;早期接触;锂;水污染物;

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