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首页> 外文期刊>Environment international >Racial differences in levels of serum lipids and effects of exposure to persistent organic pollutants on lipid levels in residents of Anniston, Alabama
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Racial differences in levels of serum lipids and effects of exposure to persistent organic pollutants on lipid levels in residents of Anniston, Alabama

机译：阿拉巴马州安尼斯顿居民的血脂水平种族差异和持久性有机污染物暴露对血脂水平的影响

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摘要

Serum lipid levels are major risk factors for cardiovascular disease. In addition to diet, exercise, genetics, age and race, serum concentrations of persistent organic pollutants (POPs) influence concentrations of serum lipids. We investigated associations between fasting concentrations of 35 polychlorinated biphenyl (PCB) congeners and nine organochlorine pesticides in relation to total serum lipids, total cholesterol, low-density lipoprotein (LDL) cholesterol, high density lipoprotein (HDL) cholesterol and triglycerides in 525 Caucasian and African American residents of Anniston, Alabama, who were not on any lipid-lowering medication. In Model 1, data were adjusted for age, age quadratic, gender, BMI, alcohol consumption, smoking and exercise, while in Model 2, additional adjustment was done for other POPs. As compared to Caucasians, African Americans had lower levels of total lipids and triglycerides with higher concentrations of HDL cholesterol, but higher concentrations of PCBs and pesticides. Total pesticides were more strongly associated with elevations in serum lipids than were total PCBs, and the associations were stronger in African Americans. Total DDTs were not associated with serum lipids after adjustment for other POPs in either racial group, while the strongest positive associations were seen for hexachlorobenzene (HCB) in both racial groups. Racial differences in lipid profiles, concentrations of POPs and associations between POP concentrations and serum lipids are relevant to racial differences in rates of cardiovascular disease.
机译：血清脂质水平是心血管疾病的主要危险因素。除了饮食，运动，遗传学，年龄和种族外，持久性有机污染物（POPs）的血清浓度还会影响血清脂质的浓度。我们调查了525名高加索人和白人中35种多氯联苯（PCB）同系物和9种有机氯农药的禁食浓度与总血脂，总胆固醇，低密度脂蛋白（LDL）胆固醇，高密度脂蛋白（HDL）胆固醇和甘油三酸酯之间的关联阿拉巴马州安尼斯顿的非裔美国人未服用任何降脂药。在模型1中，针对年龄，二次方，性别，BMI，饮酒，吸烟和运动对数据进行了调整，而在模型2中，对其他POPs进行了其他调整。与高加索人相比，非裔美国人的总脂质和甘油三酸酯含量较低，而高密度脂蛋白胆固醇含量较高，而多氯联苯和农药的含量较高。总农药与总血脂相比与多氯联苯更密切相关，并且在非洲裔美国人中这种关联更强。在调整了两个种族中的其他持久性有机污染物后，总滴滴涕与血脂没有关系，而两个种族中六氯苯（HCB）的正相关性最强。血脂谱，POPs浓度以及POPs浓度与血清脂质之间的关联的种族差异与心血管疾病发生率的种族差异有关。

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  • 来源
    《Environment international》 |2014年第12期|216-223|共8页
  • 作者

    Zafar Aminov; Richard Haase; James R. Olson; Marian Pavuk; David O. Carpenter;

  • 作者单位

    Institute for Health and the Environment, University at Albany, Rensselaer, NY 12144, United States;

    Institute for Health and the Environment, University at Albany, Rensselaer, NY 12144, United States;

    Pharmacology and Toxicology, University at Buffalo, Buffalo, NY, United States;

    Agency for Toxic Substances and Disease Registry, Atlanta, GA, United States;

    Institute for Health and the Environment, University at Albany, Rensselaer, NY 12144, United States;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    PCBs; Pesticides; Cardiovascular disease; Cholesterol; Triglycerides; HDL;

    机译：PCB;农药;心血管疾病;胆固醇;甘油三酸酯;高密度脂蛋白;

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