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Association between perfluoroalkyl substance concentrations and blood pressure in adolescents

机译：青少年全氟烷基物质浓度与血压之间的关系

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摘要

The effects of exposure to some environmental chemicals on blood pressure have been determined, but the association between non-occupational exposure to perfluoroalkyl substances (PFASs) and blood pressure in adolescents remains unknown. The association between blood pressure and PFAS concentrations was studied by analysing data from 2251 participants filtered from the population enrolled in the National Health and Nutrition Examination Survey (NHANES) from 2003 to 2012. After adjusting for age, sex, race, BM1, cotinine level, dietary intake of calcium, caloric intake, sodium consumption, potassium consumption and sampling year, we estimated the coefficients (betas) and 95% confidence intervals (Cls) for the relationship between PFAS concentrations and blood pressure with multiple linear regression models. Potential non-linear relationships were assessed with restricted cubic spline models. Blood levels of perfiuorooctane sulfonic acid (PFOS) had a strong positive association with diastolic blood pressure (DBP) in adolescents in the linear model, while the result was not significant in the non-linear model. No significant association was observed between the concentration of any other PFASs and blood pressure. According to the fully adjusted linear regression model (P = 0.041), the mean DBP values in boys in the higher PFOS quintile were 2.70% greater than the mean DBP values of boys in the lowest PFOS quintile. Furthermore, serum PFOS concentrations predominantly affected blood pressure in male adolescents compared with female adolescents. These results provide epidemiological evidence of PFOS-related increases in DBP. Further research is needed to address related issues. (C) 2019 Elsevier Ltd. All rights reserved.
机译：已经确定了暴露于某些环境化学品对血压的影响，但非职业暴露于全氟烷基物质（PFASS）和青少年血压之间的关联仍然未知。通过从2003年至2012年从纳入国家卫生和营养考试调查（NHANES）过滤的2251名参与者中，研究了血压和PFAS浓度之间的关联。调整年龄，性别，种族，BM1，Cotinine水平后，膳食摄入钙，热量摄入，钠消费，钾消费和采样年，我们估计了与多个线性回归模型的PFAS浓度和血压之间的关系的系数（β）和95％的置信区间（CLS）。用受限制的立方样条模型评估潜在的非线性关系。血红素辛烷磺酸（PFOS）的血液水平与线性模型中的青少年的舒张压（DBP）具有强烈的正相关，而在非线性模型中结果不显着。在任何其他PFASS和血压的浓度之间没有观察到明显的关联。根据完全调整的线性回归模型（P = 0.041），较高的PFOS QUINTILE中男孩的平均DBP值比最低PFOS QUINTILE中的男孩的平均DBP值大2.70％。此外，与雌性青少年相比，血清PFOS浓度主要影响雄性青少年中的血压。这些结果提供了与DBP相关的PFOS相关增加的流行病学证据。需要进一步的研究来解决相关问题。 （c）2019 Elsevier Ltd.保留所有权利。

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  • 来源
    《Environmental Pollution》 |2019年第1期|112971.1-112971.7|共7页
  • 作者

    Ma Siyu; Xu Cheng; Ma Ji; Wang Zhiqi; Zhang Yuxi; Shu Yaqin; Mo Xuming;

  • 作者单位

    Nanjing Med Univ Childrens Hosp Dept Cardiothorac Surg 72 Guangzhou Rd Nanjing 210008 Jiangsu Peoples R China;

    Nanjing Med Univ Childrens Hosp Dept Cardiothorac Surg 72 Guangzhou Rd Nanjing 210008 Jiangsu Peoples R China;

    Nanjing Med Univ Childrens Hosp Dept Cardiothorac Surg 72 Guangzhou Rd Nanjing 210008 Jiangsu Peoples R China;

    Nanjing Med Univ Childrens Hosp Dept Cardiothorac Surg 72 Guangzhou Rd Nanjing 210008 Jiangsu Peoples R China;

    Nanjing Med Univ Childrens Hosp Dept Cardiothorac Surg 72 Guangzhou Rd Nanjing 210008 Jiangsu Peoples R China;

    Nanjing Med Univ Childrens Hosp Dept Cardiothorac Surg 72 Guangzhou Rd Nanjing 210008 Jiangsu Peoples R China;

    Nanjing Med Univ Childrens Hosp Dept Cardiothorac Surg 72 Guangzhou Rd Nanjing 210008 Jiangsu Peoples R China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Perfluorooctane sulfonic acid; Blood pressure; NHANES; Adolescents;

    机译：全氟辛烷磺酸;血压;NHANES;青少年;

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