...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Environmental Pollution >Aqueous and organic extract of PM2.5 collected in different seasons and cities of Japan differently affect respiratory and immune systems
【24h】

Aqueous and organic extract of PM2.5 collected in different seasons and cities of Japan differently affect respiratory and immune systems

机译：在日本不同季节和城市收集的PM2.5的水和有机提取物对呼吸系统和免疫系统的影响不同

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Particulate matter with diameters 2.5 mu m (i.e., PM2.5) has multiple natural and anthropological sources. The association between PM2.5 and the exacerbation of respiratory allergy and asthma has been well studied, but the components of PM2.5 that are responsible for allergies have not yet been determined. Here, we elucidated the effects of aqueous and organic extract of PM2.5 collected during four seasons in November 2014 December 2015 in two cities (Kawasaki, an industrial area and Fukuoka, an urban area affected by transboundary pollution matter) of Japan on respiratory health. Ambient PM2.5 was collected by high-volume air samplers and extracted into water soluble and lipid soluble components. Human airway epithelial cells, murine bone marrow-derived antigen-presenting cells (APC) and splenocytes were exposed to PM2.5 extracts. We measured the cell viability and release of interleukin (IL)-6 and IL-8 from airway epithelial cells, the DEC205 and CD86 expressions on APCs and cell proliferation, and TCR and CD19 expression on splenocytes. The water-soluble or aqueous extracts, especially those from Kawasaki in fall, had a greater cytotoxic effect than the lipid-soluble or organic extracts in airway epithelial cells, but they caused almost no pro-inflammatory response. Extract of fall, especially the aqueous extract from Fukuoka, increased the DEC205 and CD86 expressions on APC. Moreover, aqueous extracts of fall, summer, and spring from Fukuoka significantly increased proliferation of splenocytes. Organic extract of spring and summer from Kawasaki significantly elevated the TCR expression, and organic extract of summer from Kawasaki decreased the CD19 expression. These results suggest that PM2.5 extract samples are responsible for cytotoxicity in airway epithelial cells and for activating APCs and T-cells, which can contribute to the exacerbation of respiratory diseases such as asthma. These effects can differ by PM2.5 components, collection areas and seasons. (C) 2017 Elsevier Ltd. All rights reserved.
机译：直径小于2.5微米的颗粒物（即PM2.5）具有多种自然和人类学来源。已经对PM2.5与呼吸道过敏和哮喘加重之间的关系进行了深入研究，但尚未确定引起过敏的PM2.5成分。在这里，我们阐明了2014年11月在四个季节期间在日本的两个城市（川崎市（工业区）和福冈市（受跨界污染问题影响的城市））收集的PM2.5的水和有机提取物对呼吸系统健康的影响。通过大量空气采样器收集环境PM2.5，并将其提取为水溶性和脂溶性成分。将人气道上皮细胞，鼠骨髓源性抗原呈递细胞（APC）和脾细胞暴露于PM2.5提取物中。我们测量了细胞活力和气道上皮细胞中白介素（IL）-6和IL-8的释放，APC上的DEC205和CD86表达以及细胞增殖以及脾细胞上的TCR和CD19表达。水溶性或水性提取物，尤其是秋天从川崎提取的提取物，比气道上皮细胞中的脂溶性或有机提取物具有更大的细胞毒性作用，但几乎不引起促炎反应。秋天的提取物，尤其是福冈的水提取物，增加了APC上DEC205和CD86的表达。此外，从福冈来的秋季，夏季和春季的水提物显着增加了脾细胞的增殖。川崎夏季和夏季的有机提取物显着提高了TCR的表达，川崎夏季的有机提取物降低了CD19的表达。这些结果表明，PM2.5提取物样品对气道上皮细胞的细胞毒性以及激活APC和T细胞的作用是负责的，这可能会加剧呼吸系统疾病，例如哮喘。这些影响可能因PM2.5成分，收集区域和季节而异。 （C）2017 Elsevier Ltd.保留所有权利。

著录项

  • 来源
    《Environmental Pollution》 |2018年第4期|223-234|共12页
  • 作者

    Chowdhury Pratiti Home; Okano Hitoshi; Honda Akiko; Kudou Hitomi; Kitamura Gaku; Ito Sho; Ueda Kayo; Takano Hirohisa;

  • 作者单位

    Kyoto Univ, Grad Sch Engn, Dept Environm Engn, Environm Hlth Div, Kyoto, Japan;

    Kyoto Univ, Grad Sch Engn, Dept Environm Engn, Environm Hlth Div, Kyoto, Japan;

    Kyoto Univ, Grad Sch Engn, Dept Environm Engn, Environm Hlth Div, Kyoto, Japan;

    Kyoto Univ, Grad Sch Engn, Dept Environm Engn, Environm Hlth Div, Kyoto, Japan;

    Kyoto Univ, Grad Sch Engn, Dept Environm Engn, Environm Hlth Div, Kyoto, Japan;

    Kyoto Univ, Grad Sch Engn, Dept Environm Engn, Environm Hlth Div, Kyoto, Japan;

    Kyoto Univ, Grad Sch Engn, Dept Environm Engn, Environm Hlth Div, Kyoto, Japan;

    Kyoto Univ, Grad Sch Engn, Dept Environm Engn, Environm Hlth Div, Kyoto, Japan;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号