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Estimated individual inhaled dose of fine particles and indicators of lung function: A pilot study among Chinese young adults

机译：估计的个体细颗粒吸入剂量和肺功能指标：中国年轻人的一项初步研究

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摘要

Fine particle (PM2.5)-related lung damage has been reported in most studies regarding environmental or personal PM2.5 concentrations. To assess effects of personal PM2.5 exposures on lung function, we recruited 20 postgraduate students and estimated the individual doses of inhaled PM2.5 based on their microenvironmetal PM2.5 concentrations, time-activity patterns and refereed inhalation rates. During the period of seven consecutive days in each of the four seasons, we repeatedly measured the daily lung function parameters and airway inflammation makers such as fractional exhaled nitric oxide (FeNO) as well as systemic inflammation markers including interleukin-1 beta on the final day. The high individual dose (median (IQR)) of inhaled PM2.5 was 957 (948) mu g/day. We observed a maximum FeNO increase (9.1% (95%Cl: 2.2-15.5)) at lag 0 day, a maximum decrease of maximum voluntary ventilation (11.8% (95% Cl: 4.6-19.0)) at lag 5 day and a maximum interleukin-1 beta increase (103% (95% CI: 47-159)) at lag 2 day for an interquartile range increase in the individual dose of inhaled PM2.5 during the four seasons. Shortterm exposure to PM2.5 assessed by the individual dose of inhaled PM2.5 was associated with higher airway and systemic inflammation and reduced lung function. Further studies are needed to understand better underlying mechanisms of lung damage following acute exposure to PM2.5. (C) 2017 Elsevier Ltd. All rights reserved.
机译：在大多数有关环境或个人PM2.5浓度的研究中，已经报道了与微粒（PM2.5）相关的肺损伤。为了评估个人PM2.5暴露对肺功能的影响，我们招募了20名研究生，并根据他们的微环境金属PM2.5浓度，时间活动模式和参考吸入率估算了吸入PM2.5的剂量。在四个季节的每个季节的连续七天中，我们在最后一天反复测量了每日的肺功能参数和气道发炎因素，例如呼出气一氧化氮（FeNO）以及全身性炎症标志物，包括白介素-1β 。吸入PM2.5的高单剂量（中位数（IQR））为957（948）μg /天。我们观察到在滞后0天最大的FeNO增加（9.1％（95％Cl：2.2-15.5）），在滞后5天最大自愿通风的最大减少（11.8％（95％Cl：4.6-19.0））和滞后2天，在四个季节中，吸入PM2.5的个体剂量增加了四分位间距，最大白介素1β增加（103％（95％CI：47-159））。通过单独吸入PM2.5剂量评估的短期暴露于PM2.5与更高的气道和全身炎症以及肺功能降低相关。需要进一步的研究，以了解急性暴露于PM2.5后对肺部损伤的更好的潜在机制。 （C）2017 Elsevier Ltd.保留所有权利。

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  • 来源
    《Environmental pollution》 |2018年第4期|505-513|共9页
  • 作者

    Xu Tian; Hou Jian; Cheng Juan; Zhang Runbo; Yin Wenjun; Huang Cheng; Zhu Xiaochuan; Chen Weihong; Yuan Jing;

  • 作者单位

    Huazhong Univ Sci & Technol, Sch Publ Hlth, Dept Occupat & Environm Hlth, Tongji Med Coll, Wuhan 430030, Hubei, Peoples R China;

    Huazhong Univ Sci & Technol, Sch Publ Hlth, Dept Occupat & Environm Hlth, Tongji Med Coll, Wuhan 430030, Hubei, Peoples R China;

    Huazhong Univ Sci & Technol, Sch Publ Hlth, Dept Occupat & Environm Hlth, Tongji Med Coll, Wuhan 430030, Hubei, Peoples R China;

    Huazhong Univ Sci & Technol, Sch Publ Hlth, Dept Occupat & Environm Hlth, Tongji Med Coll, Wuhan 430030, Hubei, Peoples R China;

    Huazhong Univ Sci & Technol, Sch Publ Hlth, Dept Occupat & Environm Hlth, Tongji Med Coll, Wuhan 430030, Hubei, Peoples R China;

    Huazhong Univ Sci & Technol, Sch Publ Hlth, Dept Occupat & Environm Hlth, Tongji Med Coll, Wuhan 430030, Hubei, Peoples R China;

    Huazhong Univ Sci & Technol, Sch Publ Hlth, Dept Occupat & Environm Hlth, Tongji Med Coll, Wuhan 430030, Hubei, Peoples R China;

    Huazhong Univ Sci & Technol, Sch Publ Hlth, Dept Occupat & Environm Hlth, Tongji Med Coll, Wuhan 430030, Hubei, Peoples R China;

    Huazhong Univ Sci & Technol, Sch Publ Hlth, Dept Occupat & Environm Hlth, Tongji Med Coll, Wuhan 430030, Hubei, Peoples R China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Fine particle; Maximum voluntary ventilation; Fractional exhaled nitric oxide; Interleukin-1 beta;

    机译：细颗粒;最大自主通气;部分呼出气一氧化氮;白介素-1β;

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