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首页> 外文期刊>Environmental Pollution >Assessing the effects of the antidepressant venlafaxine to fathead minnows exposed to environmentally relevant concentrations over a full life cycle
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Assessing the effects of the antidepressant venlafaxine to fathead minnows exposed to environmentally relevant concentrations over a full life cycle

机译：评估抗抑郁药文拉法辛对全生命周期暴露于环境相关浓度的黑头min的影响

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摘要

Venlafaxine is an antidepressant drug that has been detected in municipal wastewater effluents at low pg/L. concentrations. To assess the potential of this compound to affect the survival, development and reproductive capacity of fish, we exposed fathead minnow (Pimephales promelas) over a full lifecycle in a flow-through system to nominal venlafaxine concentrations of 0.88, 8.8, and 88 mu g/L. Mean measured venlafaxine concentrations in these treatments were 1.0, 93 and 75 mu g/L. During the 167-168 d exposure, no significant changes were observed in survival, or the weights and lengths of fathead minnows. At maturity, there were no significant differences relative to controls in condition factor, liver-somatic index, or secondary sex characteristics in the venlafaxine exposed male or female fish. Fathead minnows from the highest venlafaxine treatment (i.e. 88 mu g/L) produced 46% more eggs per female than control fish (p = 0.031). Egg quality, % fertilization, % hatching, and % deformities in Fl fry were unaffected by exposure of the parent fish to venlafaxine at any of the test concentrations. Venlafaxine exposure at environmentally relevant concentrations (i.e. 0.88 and 8.8 mu g/L.) caused no adverse effects in fathead minnows. This study is the first to assess the potential for effects in fish exposed to the antidepressant venlafaxine over a full lifecycle. Crown Copyright (C) 2017 Published by Elsevier Ltd. All rights reserved.
机译：文拉法辛是一种抗抑郁药，已在低pg / L的市政废水中检测到。浓度。为了评估该化合物影响鱼类生存，发育和繁殖能力的潜力，我们在流通系统的整个生命周期中使黑头head鱼（Pimephales promelas）暴露于名义上的文拉法辛浓度为0.88、8.8和88μg。 /升在这些处理中，文拉法辛的平均测量浓度为1.0、93和75μg / L。在167-168 d暴露期间，未观察到存活率或fat鱼的重量和长度的显着变化。成熟后，文拉法辛暴露的雄性或雌性鱼的条件因子，肝体指数或继发性别特征与对照组相比无显着差异。 venlafaxine最高处理（即88μg / L）的黑头生产的每只雌性卵比对照鱼多46％（p = 0.031）。在任何测试浓度下，将亲鱼暴露于文拉法辛后，不会影响卵品质，受精率，孵化率和畸形率。文拉法辛暴露于与环境有关的浓度（即0.88和8.8μg / L）不会对黑头min产生不利影响。这项研究是第一个评估在整个生命周期中暴露于抗抑郁药文拉法辛的鱼类中潜在影响的研究。 Crown版权所有（C）2017，由Elsevier Ltd.出版。保留所有权利。

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  • 来源
    《Environmental Pollution》 |2017年第10期|403-411|共9页
  • 作者

    Parrott Joanne L.; Metcalfe Chris D.;

  • 作者单位

    Environm & Climate Change Canada, Water Sci & Technol Directorate, Burlington, ON L7S 1A1, Canada;

    Trent Univ, Water Qual Ctr, Peterborough, ON, Canada;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Venlafaxine; Fathead minnow; Lifecycle; Antidepressant;

    机译：文拉法辛;F鱼;生命周期;抗抑郁药;

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