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首页> 外文期刊>Environmental toxicology and chemistry >LIFE-CYCLE EXPOSURE OF FATHEAD MINNOWS TO ENVIRONMENTALLY RELEVANT CONCENTRATIONS OF THE beta-BLOCKER DRUG PROPRANOLOL
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LIFE-CYCLE EXPOSURE OF FATHEAD MINNOWS TO ENVIRONMENTALLY RELEVANT CONCENTRATIONS OF THE beta-BLOCKER DRUG PROPRANOLOL

机译：谷的生命周期暴露与β-受体阻滞剂丙醇的环境相关浓度

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Propranolol is a human pharmaceutical beta-blocker that has been detected in municipal wastewater effluents at ng/L to low mg/L. To assess the potential of this compound to affect fish, fathead minnow (Pimephales promelas) were exposed for a life cycle in a flow-through system to nominal propranolol concentrations of 0.87 ng/L, 8.7 ng/L, 87 ng/L, 870 ng/L, and 8700 ng/L. Measured propranolol concentrations were below detection for the 2 lowest exposure concentrations, and were 76 ng/L, 580 ng/L, and 7800 ng/L for the 3 highest exposure concentrations. During the 162-d to 165-d exposure, no significant changes in weights or lengths were seen in fathead minnows, although the highest concentration of propranolol did cause a 15% decrease in survival of larval and juvenile stage fish compared with controls. At maturity, there were no significant changes in condition factor, liver-somatic index, or secondary sex characteristics in propranolol-exposed male or female fish. Female gonadosomatic index was significantly decreased in fish exposed to the highest concentrations of propranolol, probably because of increased egg-laying. Fathead minnows from all propranolol exposures produced more eggs than control fish, with fish exposed to 7800 ng/L propranolol producing 70% more eggs per female (p = 0.060), and having significantly increased clutch size (p = 0.008). Egg quality, % fertilization, % hatching, and % deformities in F1 fry were unaffected by propranolol exposure of fish. Propranolol exposure caused no effects in fathead minnows, except at the highest exposure concentration (7800 ng/L), where there were slight decreases in survival of juvenile minnows, and indications of increased reproduction. The present study is important because it is the first to assess the potential for effects in fish exposed to propranolol for a life cycle. (C) 2016 SETAC
机译：普萘洛尔是一种人用药物β受体阻滞剂，已在ng / L至低mg / L的市政废水中检测到。为了评估该化合物对鱼类的影响，将黑头now鱼（Pimephales promelas）在流通系统的生命周期中暴露于浓度为0.87 ng / L，8.7 ng / L，87 ng / L，870的普萘洛尔中ng / L和8700 ng / L。对于2个最低暴露浓度，测得的普萘洛尔浓度低于检测值，对于3个最高暴露浓度，测得的普萘洛尔浓度分别为76 ng / L，580 ng / L和7800 ng / L。在162天至165天的暴露期间，fat鱼的now鱼体重或长度没有显着变化，尽管普萘洛尔的最高浓度确实使幼鱼和幼鱼的存活率降低了15％。成熟时，普萘洛尔暴露的雄性或雌性鱼的条件因子，肝体指数或次要性别特征均无显着变化。暴露于心得安浓度最高的鱼类中，雌性性腺激素指数显着降低，这可能是由于产卵增加所致。暴露于所有普萘洛尔的黑头min生产的卵比对照鱼多，暴露于7800 ng / L普萘洛尔的鱼每只雌性多产70％的卵（p = 0.060），并且离体大小明显增加（p = 0.008）。普萘洛尔对鱼的暴露不会影响F1鱼苗的卵质量，受精率，孵化率和畸形率。普萘洛尔的暴露对黑头min鱼没有影响，除非在最高暴露浓度（7800 ng / L）下，min鱼的存活率略有下降，并表明繁殖增加。本研究很重要，因为它是第一个评估在生命周期中暴露于心得安的鱼类中潜在影响的研究。 （C）2016年SETAC

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