...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Environmental Pollution >Developmental toxicity of glycine-coated silica nanoparticles in embryonic zebrafish
【24h】

Developmental toxicity of glycine-coated silica nanoparticles in embryonic zebrafish

机译：甘氨酸包覆的二氧化硅纳米粒子在斑马鱼胚胎中的发育毒性

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Nanoparticle (NP) surface coatings are known to influence the toxicity of engineered nanomaterials. This work examines the effect of glycine functionalization on silica NPs and investigates changes in viability and developmental defects in the organs of zebrafish embryos upon exposure. Silica NPs and glycine-functionalized silica NPs are synthesized and characterized. Exposure of zebrafish embryos to glycine-silica NPs affects the mortality percentage in a similar manner to soluble glycine. Developmental defects are observed in embryos exposed to soluble glycine, glycine-silica NPs, or silica NPs in comparison with the unexposed embryos. The damage is localized in the brain, heart, and liver of zebrafish embryos. These observations suggest a complex mechanism of toxicity, with glycine maintaining its toxic activity even when covalently bound on silica surface. Our results illustrate that surface modification of non-lethal particles can create different toxicity outcomes in the organs of exposed zebrafish embryos. (C) 2017 Elsevier Ltd. All rights reserved.
机译：已知纳米颗粒（NP）表面涂层会影响工程纳米材料的毒性。这项工作审查了甘氨酸功能化对二氧化硅纳米粒的影响，并研究了斑马鱼胚胎器官暴露后活力和发育缺陷的变化。合成并表征了二氧化硅纳米粒和甘氨酸官能化的二氧化硅纳米粒。斑马鱼胚胎暴露于甘氨酸-二氧化硅纳米颗粒以类似于可溶性甘氨酸的方式影响死亡率。与未暴露的胚胎相比，在暴露于可溶性甘氨酸，甘氨酸-二氧化硅NP或二氧化硅NP的胚胎中观察到发育缺陷。损害位于斑马鱼胚胎的大脑，心脏和肝脏。这些观察结果提示了复杂的毒性机理，甘氨酸即使共价结合在二氧化硅表面上也能保持其毒性活性。我们的结果表明，非致死性颗粒的表面修饰可在暴露的斑马鱼胚胎器官中产生不同的毒性结果。 （C）2017 Elsevier Ltd.保留所有权利。

著录项

  • 来源
    《Environmental Pollution》 |2017年第10期|439-447|共9页
  • 作者

    Dumitrescu Eduard; Karunaratne Dinusha P.; Prochaska Morgan K.; Liu Xiaobo; Wallace Kenneth N.; Andreescu Silvana;

  • 作者单位

    Clarkson Univ, Dept Chem & Biomol Sci, 8 Clarkson Ave, Potsdam, NY 13699 USA;

    Clarkson Univ, Dept Chem & Biomol Sci, 8 Clarkson Ave, Potsdam, NY 13699 USA;

    Clarkson Univ, Dept Biol, 8 Clarkson Ave, Potsdam, NY 13699 USA;

    Clarkson Univ, Dept Chem & Biomol Sci, 8 Clarkson Ave, Potsdam, NY 13699 USA;

    Clarkson Univ, Dept Biol, 8 Clarkson Ave, Potsdam, NY 13699 USA;

    Clarkson Univ, Dept Chem & Biomol Sci, 8 Clarkson Ave, Potsdam, NY 13699 USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Silica nanoparticles; Nanotoxicity; glycine; Zebrafish embryos;

    机译：二氧化硅纳米颗粒;纳米毒性;甘氨酸;斑马鱼胚胎;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号