Abundance of carbapenemase, genes (bla(KPC), bla(NDM) and bla(OXA-48)) in wastewater effluents from Tunisian hospitals

Nasri Emna; Subirats Jessica; Sanchez-Melsio Alexandre; Ben Mansour Hedi; Borrego Caries M.; Luis Balcazar Jose

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Abundance of carbapenemase, genes (bla(KPC), bla(NDM) and bla(OXA-48)) in wastewater effluents from Tunisian hospitals

机译：突尼斯医院废水中的碳青霉烯酶，基因（bla（KPC），bla（NDM）和bla（OXA-48））丰富

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Carbapenems are 3-lactam antibiotics with a broad spectrum of activity and are usually considered the last resort for the treatment of severe infections caused by multidrug-resistant pathogens. The clinically most significant carbapenemases are KPC, NDM, and OXA-48-like enzymes, whose genes have been increasingly reported worldwide in members of the family Enterobacteriaceae. In this study, we quantified the abundance of these genes in wastewater effluents from different Tunisian hospitals. The bIa(NDM) and bla(OXA-48)-like genes were detected at similar concentrations in all hospital wastewater effluents. In contrast, the bla(KPC) gene was detected at lower concentration than other genes and it was only detected in three of the seven effluents analyzed. To the best of our knowledge, this study quantified for the first time the abundance of bla(KPC), bla(NDM), and bla(OXA-48)-like genes in wastewater effluents from Tunisian hospitals, highlighting the widespread distribution of these carbapenemase genes. (C) 2017 Elsevier Ltd. All rights reserved.

机译：碳青霉烯类是具有广泛活性的3-内酰胺抗生素，通常被认为是治疗由耐多药病原体引起的严重感染的最后手段。临床上最重要的碳青霉烯酶是KPC，NDM和OXA-48样酶，其基因已在全世界肠杆菌科成员中得到越来越多的报道。在这项研究中，我们量化了来自突尼斯不同医院废水中这些基因的丰度。在所有医院废水中都以相似的浓度检测到了bIa（NDM）和bla（OXA-48）样基因。相反，检测到的bla（KPC）基因的浓度低于其他基因，仅在分析的7种废水中的3种中检测到。据我们所知，本研究首次量化了突尼斯医院废水中bla（KPC），bla（NDM）和bla（OXA-48）样基因的丰度，突显了这些基因的广泛分布碳青霉烯酶基因。（C）2017 Elsevier Ltd.保留所有权利。

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来源
《Environmental Pollution》 |2017年第10期|371-374|共4页
作者
Nasri Emna; Subirats Jessica; Sanchez-Melsio Alexandre; Ben Mansour Hedi; Borrego Caries M.; Luis Balcazar Jose;
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作者单位

Univ Monastir, Res Unit Anal & Proc Appl Environm, APAE Higher Inst Appl Sci & Technol Mahdia, Monastir, Tunisia|Univ Tunis El Manar, Fac Sci, Univ Campus, Tunis, Tunisia;

Univ Girona, Catalan Inst Water Res ICRA, Sci & Technol Pk, Girona, Spain;

Univ Girona, Catalan Inst Water Res ICRA, Sci & Technol Pk, Girona, Spain;

Univ Monastir, Res Unit Anal & Proc Appl Environm, APAE Higher Inst Appl Sci & Technol Mahdia, Monastir, Tunisia;

Univ Girona, Catalan Inst Water Res ICRA, Sci & Technol Pk, Girona, Spain|Univ Girona, Inst Aquat Ecol, Grp Mol Microbial Ecol, Girona, Spain;

Univ Girona, Catalan Inst Water Res ICRA, Sci & Technol Pk, Girona, Spain;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类
关键词
Hospital effluents; Antibiotic resistance; Carbapenemase genes;

机译：医院污水;抗生素耐药性;碳青霉烯酶基因;

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专利

1. blaKPC, blaNDM, blaVIM and blaOXA-48]]> [J] . Journal of Microbiological Methods . 2017,第期

机译：<！[CDATA [CDATA [一种多重实时PCR，用于直接，快速，经济和同时检测碳结构酶基因的 BLA KPC， BLA ndm， bla vim和 bla oxa-48]]>
2. Real-time PCR assays for the detection and quantification of carbapenemase genes (bla(KPC), bla(NDM), and bla(OXA-48)) in environmental samples [J] . Subirats Jessica, Royo Elena, Luis Balcazar Jose, Environmental Science and Pollution Research . 2017,第7期

机译：在环境样品中检测和定量Carbapenemase基因（BLA（KPC），BLA（NDM）和BLA（OXA-48）的实时PCR测定法
3. Rapid Detection of bla(NDM), bla(KPC), bla(IMP), and bla(VIM) Carbapenemase Genes in Bacteria by Loop-Mediated Isothermal Amplification [J] . Cheng Cancan, Zheng Fen, Rui Yongyu Microbial drug resistance: MDR : Mechanisms, epidemiology, and disease . 2014,第6期

机译：通过环介导的等温扩增快速检测细菌中的bla（NDM），bla（KPC），bla（IMP）和bla（VIM）碳青霉烯酶基因
4. Generalized BIE-BLA formulation of skin and proximity effect problems for an arbitrary regime of the magnetic field generation [C] . Yuferev, S.V. . 1994

机译：针对任意磁场产生的皮肤和邻近效应问题的广义BIE-BLA公式
5. On the role of search in generating high-performance BLAS libraries. [D] . Yotov, Kamen Yotov. 2006

机译：关于搜索在生成高性能BLAS库中的作用。
6. Detection of P. aeruginosa harboring bla CTX-M-2 bla GES-1 and bla GES-5 bla IMP-1 and bla SPM-1 causing infections in Brazilian tertiary-care hospital [O] . Milena Polotto, Tiago Casella, Maria Gabriela de Lucca Oliveira, 2012

机译：在巴西三级医院检测出感染了bla CTX-M-2bla GES-1和bla GES-5bla IMP-1和bla SPM-1的铜绿假单胞菌
7. Rapid and Simultaneous Detection of Genes Encoding Klebsiella pneumoniae Carbapenemase ( bla KPC ) and New Delhi Metallo-β-Lactamase ( bla NDM ) in Gram-Negative Bacilli [O] . Scott A. Cunningham, Tabassum Noorie, Daniele Meunier, 2013

机译：快速同时检测编码Klebsiella肺炎肠道蛋白酶（BLA KPC）和新德里金属-β-内酰胺酶（BLA NDM）的基因在革兰氏阴性杆菌中

Abundance of carbapenemase, genes (bla(KPC), bla(NDM) and bla(OXA-48)) in wastewater effluents from Tunisian hospitals

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