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首页> 外文期刊>Environmental research >Wood dust and urinary 15-F_(2t) isoprostane in Italian industry workers
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Wood dust and urinary 15-F_(2t) isoprostane in Italian industry workers

机译：意大利工业工人的木屑和尿中15-F_（2t）异前列腺素

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Wood dust is one of the most common occupational exposures, with about 3.6 million of workers in the wood industry in Europe. Wood particles can deposit in the nose and the respiratory tract and cause adverse health effects. Occupational exposure to wood dust has been associated with malignant tumors of the nasal cavity and paranasal sinuses. The induction of oxidative stress and the generation of reactive oxygen species through activation of inflammatory cells could have a role in the carcinogenicity of respirable wood dust. Therefore, we conducted a cross-sectional study to evaluate the prevalence of urinary 15-F-2t isoprostane (15-F-2t-IsoP), a biomarker of oxidative stress and peroxidation of lipids, in 123 wood workers compared to 57 unexposed controls living in Tuscany region, Italy. 15-F-2t-IsoP generation was measured by ELISA. The main result of the present study showed that a statistically significant excess of this biomarker occurred in the workers exposed to 1.48 mg/m(3) of airborne wood dust with respect to the unexposed controls. The overall mean ratio (MR) between the workers exposed to wood dust and the controls was 1.36, 95% Confidence Interval (C.I.) 1.18-1.57, after correction for age and smoking habits. A significant increment of 15-F-2t-IsoP (43%) was observed in the smokers as compared to the non-smokers. The urinary excretion of 15-F-2t-IsoP was significantly associated with co-exposure to organic solvents, i.e., MR of 1.41, 95% C.I. 1.17-1.70, after adjustment for age and smoking habits. A 41% excess was observed in long-term wood workers, 95% C.I. 1.14-1.75. Multivariate regression analysis showed that the level of 15-F-2t-IsoP was linearly correlated to the length of exposure, regression coefficient (beta) = 0.244 +/- 0.002 (SE). The overall increment by exposure group persisted after stratification for smoking habits. For instance, in smokers, a 53% excess was detected in the wood workers as compared to the controls, 95% C.I. 1.23-1.91. Our data support the hypothesis that oxidative stress and lipid peroxidation can have a role in the toxicity of wood dust F-2-IsoP measure can be a tool for the evaluation of the effectiveness of targeted interventions aimed to reduce exposures to environmental carcinogens.
机译：木粉尘是最常见的职业暴露之一，在欧洲木业中约有360万工人。木材颗粒会沉积在鼻子和呼吸道中，并对健康产生不利影响。职业接触木屑与鼻腔和鼻旁窦的恶性肿瘤有关。通过激活炎性细胞来诱导氧化应激并产生活性氧，可能对可吸入木屑的致癌性起作用。因此，我们进行了一项横断面研究，以评估123名木工的尿中15-F-2t异前列腺素（15-F-2t-IsoP）的存在，该指标是氧化应激和脂质过氧化的生物标志物，而未暴露的对照组为57名住在意大利的托斯卡纳地区。通过ELISA测量15-F-2t-IsoP的产生。本研究的主要结果表明，与未暴露的对照组相比，在暴露于1.48 mg / m（3）的空气传播木屑的工人中，该生物标志物的统计学含量显着过量。校正年龄和吸烟习惯后，接触木屑的工人与对照组之间的总体平均比率（MR）为1.36，95％的置信区间（C.I.）为1.18-1.57。与不吸烟者相比，吸烟者中15-F-2t-IsoP显着增加（43％）。 15-F-2t-IsoP的尿排泄与有机溶剂的共同暴露显着相关，即MR为1.41，C.I为95％。调整年龄和吸烟习惯后的1.17-1.70。长期木工95％C.I.中观察到过量41％。 1.14-1.75。多元回归分析表明15-F-2t-IsoP的水平与暴露时间呈线性相关，回归系数β= 0.244 +/- 0.002（SE）。吸烟习惯分层后，暴露组的总体增加持续存在。例如，在吸烟者中，木工检测到的过量率为53％，而对照组为95％。 1.23-1.91。我们的数据支持以下假设：氧化应激和脂质过氧化可对木屑的毒性起作用。F-2-IsoP措施可作为评估旨在减少与环境致癌物接触的目标干预措施有效性的工具。

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