...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Environmental research >Perfluoroalkyl acids serum concentrations and their relationship to biomarkers of renal failure: Serum and urine albumin, creatinine, and albumin creatinine ratios across the spectrum of glomerular function among US adults
【24h】

Perfluoroalkyl acids serum concentrations and their relationship to biomarkers of renal failure: Serum and urine albumin, creatinine, and albumin creatinine ratios across the spectrum of glomerular function among US adults

机译：全氟烷基的血清浓度及其与肾衰竭的生物标志物的关系：美国成年人肾小球功能频谱中的血清和尿白蛋白，肌酐和白蛋白肌酐比率

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Associations between selected perfluoroalkyl acids (PFAAs) and biomarkers of renal function were evaluated for US adult aged = 20 years (N = 8220) in the National Health and Nutrition Examination Survey for 2005-2014. Glomerular filtration (GF) stage-stratified regression models were classified by estimated glomerular filtration rate (eGFR) with GF-1 (eGFR 90 mL/min/1.73 m(2)), GF-2 (eGFR 60-89 mL/min/1.73 ma), GF-3A (45-59 mL/min/1.73 m(2)), and GF-3B/4 (15-44 mL/min/1.73 m(2)). For GF-1, PFOA, PFOS, and PFHxS were positively and significantly associated with serum creatinine. Serum albumin levels were positively associated with the PFAA considered at all stages and most associations were significant. Further, PFAS serum concentration associations to serum albumin were about 2-3 times stronger at GF-3B/4 than at GF-1. In contrast, urine albumin was negatively and significantly associated with PFOA and PFHxS serum concentrations at all stages of renal function, while, PFOS and PFNA were negatively and significantly associated to urine albumin at GF-3A and GF-3B/4. Urine albumin/creatinine ratios were negatively and significantly associated with PFOA, PFOS, and, and PFHxS serum concentrations at all stages of renal function, as well as with PFNA and PFDA at GF-3A and GF-3B/4. Recent work revealed that serum PFAAs have an inverted U-shaped association to the calculated stages of renal failure based on eGFR; this work adds that albuminuria makes additional negative contributions to already existing negative associations of PFAA to eGFR in advancing stages of renal failure. We hypothesize that both progressive renal failure per se and especially renal failure with albuminuria cause the kidneys to reabsorb less and to excrete more of the PFAAs studied. We suspect this finding may generalize to some other perfluoroalkyl substances (PFAS). The findings also imply study design considerations for evaluating associations to diseases and biomarkers associated with renal failure, such as diabetes.
机译：在2005-2014年美国国家健康和营养调查中，对年龄≥20岁的美国成年人（N = 8220）评估了选定的全氟烷基酸（PFAA）与肾功能生物标志物之间的关联。肾小球滤过（GF）阶段分层的回归模型通过估计的肾小球滤过率（eGFR）进行分类，其中GF-1（eGFR> 90 mL / min / 1.73 m（2）），GF-2（eGFR 60-89 mL / min /1.73 ma），GF-3A（45-59 mL / min / 1.73 m（2））和GF-3B / 4（15-44 mL / min / 1.73 m（2））。对于GF-1，PFOA，PFOS和PFHxS与血清肌酐呈正相关且显着相关。在所有阶段中，血清白蛋白水平与PFAA呈正相关，并且大多数相关性均显着。此外，在GF-3B / 4时，PFAS血清浓度与血清白蛋白的关系比在GF-1时强约2-3倍。相反，在肾功能的所有阶段，尿白蛋白与PFOA和PFHxS血清浓度呈负相关且显着相关，而在GF-3A和GF-3B / 4时，PFOS和PFNA与尿白蛋白呈负相关且显着相关。尿白蛋白/肌酐比值与肾功能各个阶段的PFOA，PFOS和PFHxS血清浓度以及GF-3A和GF-3B / 4的PFNA和PFDA呈负相关且显着相关。最近的研究表明，血清PFAAs与基于eGFR的肾功能衰竭的计算阶段呈倒U形关联。这项工作补充说，在肾衰竭的发展阶段，白蛋白尿对PFAA与eGFR的负相关已经产生了其他负面影响。我们假设，进行性肾衰竭本身，尤其是伴有蛋白尿的肾衰竭，都会导致肾脏吸收更少，并排泄更多的PFAA。我们怀疑这一发现可能会推广到其他一些全氟烷基物质（PFAS）。该发现还暗示研究设计时应考虑到与糖尿病等肾衰竭相关疾病和生物标志物的关联性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号