...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Environmental research >Perfluoroalkyl acids serum concentrations and their relationship to biomarkers of renal failure: Serum and urine albumin, creatinine, and albumin creatinine ratios across the spectrum of glomerular function among US adults
【24h】

Perfluoroalkyl acids serum concentrations and their relationship to biomarkers of renal failure: Serum and urine albumin, creatinine, and albumin creatinine ratios across the spectrum of glomerular function among US adults

机译：全氟烷基酸血清浓度及其与肾功能衰竭的生物标志物的关系：血清和尿液白蛋白，肌酐和白蛋白肌酐毒素比在美国成年人中的肾小球功能范围

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Associations between selected perfluoroalkyl acids (PFAAs) and biomarkers of renal function were evaluated for US adult aged = 20 years (N = 8220) in the National Health and Nutrition Examination Survey for 2005-2014. Glomerular filtration (GF) stage-stratified regression models were classified by estimated glomerular filtration rate (eGFR) with GF-1 (eGFR 90 mL/min/1.73 m(2)), GF-2 (eGFR 60-89 mL/min/1.73 ma), GF-3A (45-59 mL/min/1.73 m(2)), and GF-3B/4 (15-44 mL/min/1.73 m(2)). For GF-1, PFOA, PFOS, and PFHxS were positively and significantly associated with serum creatinine. Serum albumin levels were positively associated with the PFAA considered at all stages and most associations were significant. Further, PFAS serum concentration associations to serum albumin were about 2-3 times stronger at GF-3B/4 than at GF-1. In contrast, urine albumin was negatively and significantly associated with PFOA and PFHxS serum concentrations at all stages of renal function, while, PFOS and PFNA were negatively and significantly associated to urine albumin at GF-3A and GF-3B/4. Urine albumin/creatinine ratios were negatively and significantly associated with PFOA, PFOS, and, and PFHxS serum concentrations at all stages of renal function, as well as with PFNA and PFDA at GF-3A and GF-3B/4. Recent work revealed that serum PFAAs have an inverted U-shaped association to the calculated stages of renal failure based on eGFR; this work adds that albuminuria makes additional negative contributions to already existing negative associations of PFAA to eGFR in advancing stages of renal failure. We hypothesize that both progressive renal failure per se and especially renal failure with albuminuria cause the kidneys to reabsorb less and to excrete more of the PFAAs studied. We suspect this finding may generalize to some other perfluoroalkyl substances (PFAS). The findings also imply study design considerations for evaluating associations to diseases and biomarkers associated with renal failure, such as diabetes.
机译：在2005 - 2014年美国国家卫生和营养考试调查中，对美国成人年龄（N = 8220）评估了选定的全氟烷基酸（PFAAs）和肾功能的生物标志物之间的缔组织。通过GF-1（EGFR> 90mL / min / 1.73m（2）），GF-2（EGFR 60-89ml / min / min / min，通过估计的肾小球过滤速率（EGFR）来分类肾小球过滤（EGFR）分类/1.73 mA），GF-3a（45-59ml / min / 1.73 m（2））和GF-3B / 4（15-44ml / min / 1.73 m（2））。对于GF-1，PFOA，PFO和PFHxs呈正且显着与血清肌酐有关。血清白蛋白水平与所有阶段考虑的PFAA正相关，大多数关联都是显着的。此外，PFAS血清浓度关联与血清白蛋白的缔肾上腺素在GF-3B / 4中较强约2-3倍，而不是GF-1。相反，尿白蛋白与肾功能的所有阶段的PFOA和PFHXS血清浓度显着相关，而PFOS和PFNA与GF-3A和GF-3B / 4的尿白蛋白显着相关。尿液白蛋白/肌酐比率与肾功能的所有阶段的PFOA，PFO和PFHXS血清浓度显着，以及GF-3A和GF-3B / 4的PFNA和PFDA。最近的工作表明，血清PFAAS具有基于EGFR的肾衰竭的计算阶段的倒U形结合;这项工作补充说，白蛋白尿对已经存在PFAA的负面关联对EGFR在推进肾功能衰竭的阶段进行额外的负面贡献。我们假设术语肾功能衰竭本身和尤其是肾蛋白尿的肾功能衰竭导致肾脏重新吸收较少并排出更多的PFAAs。我们怀疑此发现可能会推广到其他一些全氟烷基物质（PFAS）。调查结果也意味着研究设计考虑，用于评估与肾功能衰竭相关的疾病和生物标志物的关联，例如糖尿病。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号