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Short-term exposures to particulate matter gamma radiation activities and biomarkers of systemic inflammation and endothelial activation in COPD patients

机译：短期暴露于颗粒物质γ辐射活性和对COPD患者的全身炎症和内皮激活的生物标志物

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摘要

Background: We hypothesized that particulate matter (PM) gamma activity (gamma radiation associated with PM) is associated with systemic effects. Objective: Examine short-term relationships between ambient and indoor exposures to PM gamma activities with systemic inflammation and endothelial activation in chronic obstructive pulmonary disease (COPD) patients. Methods: In 85 COPD patients from Eastern Massachusetts, USA from 2012 to 2014, plasma C-reactive protein (CRP), interleukin-6 (IL-6), and soluble vascular cell adhesion molecule-1 (sVCAM-1) were measured seasonally up to four times. We used US EPA RadNet data measuring ambient gamma radiation attached to PM adjusted for background radiation, and estimated in-home gamma radiation exposures using the ratio of in-home-to-ambient sulfur in PM_(2.5). Linear mixed-effects regression models were used to determine associations between moving averages of PM gamma activities through the week before phlebotomy with these biomarkers. We explored ambient and indoor PM_(2.5), black carbon (BC), and NO_2 as confounders. Results: Ambient and indoor PM gamma activities measured as energy spectra classes 3 through 9 were positively associated with CRP and IL-6. For example, averaged from phlebotomy day through previous 6 days, each IQR increase in indoor PM gamma activity for each spectra class, was associated with an CRP increase ranging from 7.45% (95%CI: 2.77, 12.4) to 13.4% (95%CI: 5.82, 21.4) and for ambient exposures were associated with an increase of 8.75% (95%CI: -0.57, 18.95) to 14.8% (95%CI: 4.5, 26.0). Indoor exposures were associated with IL-6 increase of 3.56% (95%CI: 0.31, 6.91) to 6.46% (95%CI:1.33, 11.85) and ambient exposures were associated with an increase of 0.03% (95%CI: -6.37, 6.87) to 3.50% (95%CI: -3.15, 10.61). There were no positive associations with sVCAM-1. Sensitivity analyses using two-pollutant models showed similar effects. Conclusions: Our results demonstrate that short-term exposures to environmental PM gamma radiation activities were associated with systemic inflammation in COPD patients.
机译：背景：我们假设颗粒物质（PM）γ活性（与PM相关的γ辐射）与全身效应有关。目的：审查环境和室内暴露于PMγ活性的短期关系，具有全身炎症和慢性阻塞性肺病（COPD）患者的内皮激活。方法：在2012年至2014年美国东部马萨诸塞州的85名COPD患者中，测定季节性血浆C-反应蛋白（CRP），白细胞介素-6（IL-6）和可溶性血管细胞粘附分子-1（SVCAM-1）最多四次。我们使用美国EPA RAMNET数据测量环境伽玛辐射，该伽马辐射附着于PM调节的背景辐射，并使用PM_（2.5）中的家庭环境硫的比例估计在家用伽马辐射曝光。线性混合效应回归模型用于确定PMγ活性的移动平均值在与这些生物标志物的一周前一周的伽马活动之间的缔合。我们探索了环境和室内PM_（2.5），黑碳（BC）和NO_2作为混乱。结果：作为能量谱类3到9测量的环境和室内PM伽玛活动与CRP和IL-6正相关。例如，从Phlebotomy日期通过前6天的平均，每个Specta类的室内PMγ活性的每个IQR增加与3.45％（95％CI：2.77,12.4）的CRP增加相关的CRP增加到13.4％（95％） CI：5.82,21.4）和环境暴露的增加与8.75％（95％CI：-0.57,18.95）增加至14.8％（95％CI：4.5,26.0）。室内曝光与IL-6增加3.56％（95％CI：0.31,6.91）至6.46％（95％CI：1.33,11.85）和环境暴露的增加0.03％（95％CI： - 6.37,6.87）至3.50％（95％CI：-3.15,10.61）。没有SVCAM-1没有积极的关联。使用双污染物模型的敏感性分析显示出类似的效果。结论：我们的结果表明，对环境PMγ辐射活性的短期暴露与COPD患者的全身炎症有关。

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  • 来源
    《Environmental research》 |2020年第1期|33.1-33.8|共8页
  • 作者

    Shaodan Huang; Eric Garshick; Carolina L.Z. Vieira; Stephanie T. Grady; Joel D. Schwartz; Brent A. Coull; Jaime E. Hart; Francine Laden; Petros Koutrakis;

  • 作者单位

    Department of Environmental Health Harvard T.H. Chan School of Public Health Boston MA USA;

    Pulmonary Allergy Sleep and Critical Care Medicine Section Medical Service VA Boston Healthcare System Boston MA USA Channing Division of Network Medicine Department of Medicine Brigham and Women's Hospital Harvard Medical School Boston MA USA;

    Department of Environmental Health Harvard T.H. Chan School of Public Health Boston MA USA;

    Channing Division of Network Medicine Department of Medicine Brigham and Women's Hospital Harvard Medical School Boston MA USA Research and Development Service VA Boston Healthcare System Boston MA USA;

    Department of Environmental Health Harvard T.H. Chan School of Public Health Boston MA USA Channing Division of Network Medicine Department of Medicine Brigham and Women's Hospital Harvard Medical School Boston MA USA Department of Epidemiology Harvard T.H. Chan School of Public Health Boston MA USA;

    Department of Environmental Health Harvard T.H. Chan School of Public Health Boston MA USA Department of Biostatistics Harvard T.H. Chan School of Public Health Boston MA USA;

    Department of Environmental Health Harvard T.H. Chan School of Public Health Boston MA USA Channing Division of Network Medicine Department of Medicine Brigham and Women's Hospital Harvard Medical School Boston MA USA;

    Department of Environmental Health Harvard T.H. Chan School of Public Health Boston MA USA Channing Division of Network Medicine Department of Medicine Brigham and Women's Hospital Harvard Medical School Boston MA USA Department of Epidemiology Harvard T.H. Chan School of Public Health Boston MA USA;

    Department of Environmental Health Harvard T.H. Chan School of Public Health Boston MA USA;

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  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    Gamma radiation; Particulate matter (PM); Particulate matter gamma radiation activities; Systemic inflammatory biomarkers; Chronic obstructive pulmonary disease (COPD);

    机译：伽玛辐射;颗粒物质（PM）;颗粒物质γ辐射活动;全身炎症生物标志物;慢性阻塞性肺病（COPD）;

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