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A framework for assessing the impact of chemical exposures on neurodevelopment in ECHO: Opportunities and challenges

机译：评估化学曝光对echo中神经发育的影响的框架：机遇和挑战

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摘要

The Environmental influences on Child Health Outcomes (ECHO) Program is a research initiative funded by the National Institutes of Health that capitalizes on existing cohort studies to investigate the impact of early life environmental factors on child health and development from infancy through adolescence. In the initial stage of the program, extant data from 70 existing cohort studies are being uploaded to a database that will be publicly available to researchers. This new database will represent an unprecedented opportunity for researchers to combine data across existing cohorts to address associations between prenatal chemical exposures and child neurodevelopment. Data elements collected by ECHO cohorts were determined via a series of surveys administered by the ECHO Data Analysis Center. The most common chemical classes quantified in multiple cohorts include organophosphate pesticides, polychlorinated biphenyls, polybrominated diphenyl ethers, environmental phenols (including bisphenol A), phthalates, and metals. For each of these chemicals, at least four ECHO cohorts also collected behavioral data during infancy/early childhood using the Child Behavior Checklist. For these chemicals and this neurodevelopmental assessment (as an example), existing data from multiple ECHO cohorts could be pooled to address research questions requiring larger sample sizes than previously available. In addition to summarizing the data that will be available, the article also describes some of the challenges inherent in combining existing data across cohorts, as well as the gaps that could be filled by the additional data collection in the ECHO Program going forward.
机译：对儿童健康成果（ECHO）计划的环境影响是由国家卫生研究院资助的研究倡议，以利用现有的队列研究，以调查早期生命环境因素对来自青春期的婴儿健康和发展的影响。在程序的初始阶段，从70个现有队列研究的现存数据上传到将公开对研究人员公开使用的数据库。这个新数据库将代表研究人员将数据与现有队列中的数据结合起来以解决产前化学曝光和儿童神经发作之间的关联的前所未有的机会。回波群组收集的数据元素通过由回声数据分析中心管理的一系列调查确定。多个队列中量化的最常见的化学类别包括有机磷农药，多氯联苯，聚溴二苯醚，环境酚（包括双酚A），邻苯二甲酸盐和金属。对于这些化学品中的每一个，至少四个回声队列也使用儿童行为清单在婴儿期/早期儿童期间收集行为数据。对于这些化学品和这种神经发育评估（例如示例），可以汇集来自多个回波队列的现有数据，以解决需要比以前可用的更大样本大小的研究问题。除了总结将提供的数据外，文章还介绍了组合跨伙伴的现有数据以及可以在呼应程序前进的附加数据收集填充的空白所固有的一些挑战。

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  • 来源
    《Environmental research》 |2020年第9期|109709.1-109709.22|共22页
  • 作者

    Susan L. Schantz; Brenda Eskenazi; Jessie P. Buckley; Joseph M. Braun; Jenna N. Sprowles; Deborah H. Bennett; Jose Cordero; Jean A. Frazier; Johnnye Lewis; Irva Hertz-Picciotto; Kristen Lyall; Sara S. Nozadi; Sharon Sagiv; AnneMarie Stroustrup; Heather E. Volk; Deborah J. Watkins;

  • 作者单位

    Department of Comparative Biosciences College of Veterinary Medicine and Beckman Institute for Advanced Science and Technology University of Illinois at Urbana-Champaign Urbana IL USA;

    Center for Environmental Research and Children's Health School of Public Health University of California Berkeley Berkeley CA USA;

    Department of Environmental Health and Engineering Bloomberg School of Public Health Johns Hopkins University Baltimore MD USA;

    Department of Epidemiology Brown University Providence RI USA;

    Beckman Institute for Advanced Science and Technology University of Illinois at Urbana-Champaign Urbana IL USA;

    Department of Public Health Sciences University of California Davis CA USA;

    Department of Epidemiology and Biostatistics College of Public Health University of Georgia Athens GA USA;

    Eunice Kennedy Shriver Center Division of Child and Adolescent Psychiatry University of Massachusetts Medical School Worcester MA USA;

    Community Environmental Health Program and Center for Native Environmental Health Equity Research College of Pharmacy University of New Mexico Health Sciences Center Albuquerque NM USA;

    Department of Public Health Sciences University of California Davis CA USA;

    A.J. Drexel Autism Institute Drexel University Philadelphia PA USA;

    Community Environmental Health Program and Center for Native Environmental Health Equity Research College of Pharmacy University of New Mexico Health Sciences Center Albuquerque NM USA;

    Center for Environmental Research and Children's Health School of Public Health University of California Berkeley Berkeley CA USA;

    Division of Newborn Medicine Department of Pediatrics Department of Environmental Medicine and Public Health and Department of Obstetrics Gynecology and Reproductive Science Icahn School of Medicine at Mount Sinai New York NY USA;

    Departments of Mental Health and Environmental Health and Engineering Bloomberg School of Public Health Johns Hopkins University Baltimore MD USA;

    Department of Environmental Health Sciences University of Michigan School of Public Health Ann Arbor MI USA;

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  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    ECHO; Neurodevelopment; Prenatal chemical exposure; Infancy; Childhood;

    机译：回声;神经发作;产前化学曝光;婴儿期;童年;

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