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首页> 外文期刊>Annual Review of Physiology >Gestational Exposure to Common Endocrine Disrupting Chemicals and Their Impact on Neurodevelopment and Behavior
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Gestational Exposure to Common Endocrine Disrupting Chemicals and Their Impact on Neurodevelopment and Behavior

机译：妊娠期暴露于常见的内分泌扰乱化学品及其对神经发育和行为的影响

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摘要

Endocrine disrupting chemicals are common in our environment and act on hormone systems and signaling pathways to alter physiological homeostasis. Gestational exposure can disrupt developmental programs, permanently altering tissues with impacts lasting into adulthood. The brain is a critical target for developmental endocrine disruption, resulting in altered neuroendocrine control of hormonal signaling, altered neurotransmitter control of nervous system function, and fundamental changes in behaviors such as learning, memory, and social interactions. Human cohort studies reveal correlations between maternal/fetal exposure to endocrine disruptors and incidence of neurodevelopmental disorders. Here, we summarize the major literature findings of endocrine disruption of neurodevelopment and concomitant changes in behavior by four major endocrine disruptor classes: bisphenol A, polychlorinated biphenyls, organophosphates, and polybrominated diphenyl ethers. We specifically review studies of gestational and/or lactational exposure to understand the effects of early life exposure to these compounds and summarize animal studies that help explain human correlative data.
机译：内分泌破坏化学品在我们的环境中是常见的，并在激素系统和信号通路上采取行动，以改变生理稳态。妊娠曝光可能会破坏发展方案，永久改变持续到成年期的影响。大脑是发育内分泌破坏的关键目标，导致激素信号传导的神经内分泌控制改变，改变神经系统功能的神经递质控制，以及学习，记忆和社交互动等行为的根本变化。人群研究揭示了母婴/胎儿暴露于内分泌破坏的相关性和神经发育障碍发病率之间的相关性。在这里，我们总结了四个主要内分泌破坏剂类别的神经发育和伴随性变化的主要文献发现：双酚A，多氯联苯，有机磷酸和聚溴二苯醚。我们特别审查对妊娠和/或泌乳暴露的研究，以了解早期生命暴露对这些化合物的影响，并总结了有助于解释人类相关数据的动物研究。

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