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Prenatal phthalate exposure and placental size and shape at birth: A birth cohort study

机译：产前邻苯二甲酸盐的暴露以及出生时胎盘的大小和形状：一项出生队列研究

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摘要

Objective: There is concern over the potential placental effects of prenatal phthalate exposure, and the potential adverse effects of prenatal phthalate exposure require further study; however, few data are available in humans. We investigated the associations between phthalate exposure in each trimester and both placental size and shape at birth. Methods: We measured the urinary concentrations of phthalate metabolites among 2725 pregnant women in the Ma'anshan Birth Cohort. Before collecting urine samples from each of the three trimesters, the pregnant women were interviewed via questionnaires. Placental information was obtained from hospital records. We estimated the sex-specific associations between urinary phthalate concentrations in each trimester and both placental size and shape at birth using adjusted multiple regression. A linear mixed model was used for the repeated measures analysis with subject-specific random intercepts and slopes for gestational age at sample collection to test the effect of phthalate levels on placental size and shape and to estimate the effect sizes. Results: Overall, placental breadth increased by 0.148 cm (95% CI: 0.078, 0.218) with each 1 ln-concentration increase in MBP in the first trimester. The difference between placental length and breadth (length-breadth) decreased by 0.086cm (95% CI: -0.159, -0.012) and 0.149cm (95% CI: -0.221, -0.076) with each 1 ln-concentration increase in MMP and MBP, respectively, in the first trimester. In the second trimester, placental thickness increased by 0.017 cm (95% CI: 0.006, 0.027), 0.020 cm (95% CI: 0.004, 0.036), 0.028 cm (95% CI: 0.007, 0.048), and 0.035 cm (95% CI: 0.018, 0.053) with each 1 ln-concentration increase in MMP, MBP, MEOHP, and MEHHP, respectively. In the third trimester, placental thickness increased by 0.037 cm (95% CI: 0.019, 0.056) and 0.019 cm (95% CI: 0, 0.037) with each 1 ln-concentration increase in MBP and MEHP, respectively. Multiple linear regression for each offspring sex indicated that prenatal phthalate exposure increased placental thickness in both the first and second trimesters in males, whereas the corresponding relationship was close to null in females. Linear mixed models (LMMs) yielded similar results. Conclusion: Our results suggest the presence of associations between prenatal phthalate exposure and placental size and shape. Exposure to certain phthalates may cause the placenta to become thicker and more circular. Associations appeared stronger for the subsample representing male offspring than those for the subsample representing female offspring. Given the few studies on this topic, additional research is warranted.
机译：目的：关注产前邻苯二甲酸酯暴露的潜在胎盘效应，以及产前邻苯二甲酸酯暴露的潜在不利效应，需要进一步研究；但是，人类的数据很少。我们调查了每三个月的邻苯二甲酸酯暴露与出生时胎盘大小和形状之间的关系。方法：我们测量了马鞍山出生队列中的2725名孕妇的尿中邻苯二甲酸酯代谢物的浓度。在从三个三个月中的每个三个月收集尿液样本之前，对孕妇进行了问卷调查。胎盘信息是从医院记录中获得的。我们使用调整后的多元回归估计了每个孕期尿中邻苯二甲酸酯浓度与出生时胎盘大小和形状之间的性别特异性关联。线性混合模型用于重复测量分析，在受试者收集样本时采用特定于受试者的随机截距和胎龄的斜率进行重复测量分析，以测试邻苯二甲酸盐水平对胎盘大小和形状的影响并估算影响大小。结果：总体而言，在头三个月，MBP每增加1 ln，胎盘宽度就会增加0.148 cm（95％CI：0.078，0.218）。随着MMP浓度每增加1 ln，胎盘长度和宽度（长度-宽度）之间的差异就会减少0.086cm（95％CI：-0.159，-0.012）和0.149cm（95％CI：-0.221，-0.076）和MBP，分别在孕早期。在孕中期，胎盘厚度增加了0.017厘米（95％CI：0.006、0.027），0.020厘米（95％CI：0.004、0.036），0.028厘米（95％CI：0.007、0.048）和0.035厘米（95） ％CI：0.018、0.053），其中MMP，MBP，MEOHP和MEHHP浓度每增加1 ln。在孕晚期，胎盘厚度分别增加0.037 cm（95％CI：0.019，0.056）和0.019 cm（95％CI：0，0.037），MBP和MEHP分别增加1 ln。每种后代性别的多元线性回归表明，产前邻苯二甲酸酯暴露增加了男性在孕早期和中期的胎盘厚度，而女性的对应关系接近于零。线性混合模型（LMM）产生了相似的结果。结论：我们的结果表明，产前邻苯二甲酸酯暴露与胎盘大小和形状之间存在关联。暴露于某些邻苯二甲酸盐可能导致胎盘变厚和变圆。代表男性后代的子样本的关联似乎比代表女性后代的子样本的关联更强。鉴于对此主题的研究很少，因此有必要进行更多研究。

著录项

  • 来源
    《Environmental research》 |2018年第1期|239-246|共8页
  • 作者

    Yuan-duo Zhu; Hui Gao; Kun Huang; Yun-wei Zhang; Xiu-xiu Cai; Hui-yuan Yao; Lei-jing Mao; Xing Ge; Shan-shan Zhou; Yuan-yuan Xu; Zhong-xiu Jin; Jie Sheng; Shuang-qin Yan; Wei-jun Pan; Jia-hu Hao; Peng Zhu; Fang-biao Tao;

  • 作者单位

    Department of Maternal Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, Anhui, China;

    Department of Maternal Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, Anhui, China;

    Department of Maternal Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, Anhui, China,Anhui Provincial Key laboratory of Population Health & Aristogenics, Hefei, China;

    Department of Maternal Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, Anhui, China;

    Department of Maternal Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, Anhui, China;

    Department of Maternal Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, Anhui, China;

    Department of Maternal Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, Anhui, China;

    Department of Maternal Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, Anhui, China;

    Department of Maternal Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, Anhui, China;

    Department of Maternal Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, Anhui, China,Anhui Provincial Key laboratory of Population Health & Aristogenics, Hefei, China;

    Anhui Provincial Key laboratory of Population Health & Aristogenics, Hefei, China;

    Anhui Provincial Key laboratory of Population Health & Aristogenics, Hefei, China;

    Ma'anshan Maternal and Child Health (MCH) Center, Ma'anshan, China;

    Ma'anshan Maternal and Child Health (MCH) Center, Ma'anshan, China;

    Department of Maternal Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, Anhui, China,Anhui Provincial Key laboratory of Population Health & Aristogenics, Hefei, China;

    Department of Maternal Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, Anhui, China,Anhui Provincial Key laboratory of Population Health & Aristogenics, Hefei, China;

    Department of Maternal Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, Anhui, China,Anhui Provincial Key laboratory of Population Health & Aristogenics, Hefei, China;

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  • 正文语种 eng
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  • 关键词

    Phthalate; Exposure; Urinary metabolites; Placenta; Size and shape;

    机译：邻苯二甲酸盐接触;尿代谢产物;胎盘;尺寸和形状;

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