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首页> 外文期刊>Environmental research >Cardiometabolic profiles of adolescents and young adults exposed to the World Trade Center Disaster
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Cardiometabolic profiles of adolescents and young adults exposed to the World Trade Center Disaster

机译：暴露于世界贸易中心灾难中的青少年的青少年心脏代谢特征

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摘要

Background and objective: Few studies have examined the possible cardiometabolic consequences of World Trade Center-related exposures on children who lived and/or attended school near the disaster site. Our objective was to compare cardiometabolic profiles of participants in the World Trade Center Health Registry (WTCHR) with a matched comparison group. Methods: We evaluated WTCHR enrollees who resided in New York City and were born between September 11, 1993 and September 10, 2001, and a matched comparison group. We assessed exposure to dust cloud, home dust, as well as traumatic exposure, and associations with blood pressure, arterial wall stiffness, body mass index (BMI), total cholesterol, triglycerides, HDL, and LDL. Results: A total of 402 participants completed the study, 222 in the comparison group and 180 in the WTCHR group. In multivariable regression analysis, after adjusting for relevant confounders we detected a weak association between participation in the WTCHR group and lower BMI (-1.12 kg/m~2, 95% CI -2.11, -0.12;p = 0.03), which became non-significant after adjusting for multiple comparisons. With respect to traumatic and psychosocial exposures, the only association that persisted in our multivariable model, below our predefined level of significance, was between post-traumatic stress disorder and higher BMI (2.06 kg/m2, 95% CI 0.37, 3.74; p = 0.02). Conclusions: Our findings do not support an association between self-reported exposures to the WTC disaster and adverse cardiometabolic profile. However, further longitudinal studies may better inform the full extent of WTC-related conditions associated with exposure to the disaster.
机译：背景和目的：很少有研究检查世界贸易中心相关暴露对在灾区附近生活和/或上学的孩子的可能的心脏代谢后果。我们的目标是将世界贸易中心卫生登记处（WTCHR）参与者的心血管代谢状况与匹配的比较组进行比较。方法：我们评估了居住在纽约市且于1993年9月11日至2001年9月10日之间出生的WTCHR登记者，以及一个匹配的比较组。我们评估了暴露于尘埃云，家庭尘埃以及外伤性暴露的程度，以及与血压，动脉壁僵硬度，体重指数（BMI），总胆固醇，甘油三酸酯，HDL和LDL的关联。结果：共有402位参与者完成了研究，比较组222位，WTCHR组180位。在多变量回归分析中，在调整了相关混杂因素后，我们检测到WTCHR组的参与与较低的BMI之间存在弱关联（-1.12 kg / m〜2，95％CI -2.11，-0.12; p = 0.03），这变为非-调整多个比较后有意义。关于创伤和心理暴露，在我们的多变量模型中，持续低于我们预定义的显着性水平的唯一关联是创伤后应激障碍和较高的BMI（2.06 kg / m2，95％CI 0.37，3.74； p = 0.02）。结论：我们的发现不支持自我报告的WTC灾难暴露与不良的心脏代谢状况之间的关联。但是，进一步的纵向研究可能会更好地为与受灾相关的WTC相关状况提供全面信息。

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  • 来源
    《Environmental research》 |2018年第1期|107-114|共8页
  • 作者

    Leonardo Trasande; Tony T. Koshy; Joseph Gilbert; Lauren K. Burdine; Michael Marmor; Xiaoxia Han; Yongzhao Shao; Claude Chemtob; Teresa M. Attina; Elaine M. Urbina;

  • 作者单位

    Departments of Pediatrics, New York University School of Medicine, New York, NY, USA,Environmental Medicine, New York University School of Medicine, New York, NY, USA,Population Health, New York University School of Medicine, New York, NY, USA,NYU Wagner School of Public Service, New York, NY, USA,NYU College of Global Public Health, New York, NY, USA;

    Departments of Pediatrics, New York University School of Medicine, New York, NY, USA;

    Departments of Pediatrics, New York University School of Medicine, New York, NY, USA;

    Departments of Pediatrics, New York University School of Medicine, New York, NY, USA;

    Environmental Medicine, New York University School of Medicine, New York, NY, USA,Population Health, New York University School of Medicine, New York, NY, USA,Medicine, New York University School of Medicine, New York, NY, USA;

    Population Health, New York University School of Medicine, New York, NY, USA;

    Environmental Medicine, New York University School of Medicine, New York, NY, USA,Population Health, New York University School of Medicine, New York, NY, USA;

    Psychiatry, New York University School of Medicine, New York, NY, USA;

    Departments of Pediatrics, New York University School of Medicine, New York, NY, USA;

    Cincinnati Children's Hospital Medical Center & University of Cincinnati, Cincinnati, OH, USA;

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  • 正文语种 eng
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  • 关键词

    World Trade Center Disaster; Cardiometabolic effects; Dust exposure; Traumatic exposure;

    机译：世界贸易中心灾难;心脏代谢作用;灰尘暴露;创伤性暴露;

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