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The association between p,p'-DDE levels and left ventricular mass is mainly mediated by obesity

机译：p，p'-DDE水平与左心室重量之间的相关性主要由肥胖介导

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摘要

Background and objectives: The pesticide metabolite p,p'-DDE has been associated with left ventricular (LV) mass and known risk factors for LV hypertrophy in humans and in experimental models. We hypothesized that the associations of p,p'-DDE with LV hypertrophy risk factors, namely elevated glucose, adiposity and hypertension, mediate the association of p,p'-DDE with LV mass. Methods: p,p'-DDE was measured in plasma from 70-year-old subjects (n = 988) of the Prospective Study of the Vasculature in Uppsala Seniors (PIVUS). When these subjects were 70-, 75- and 80- years old, LV characteristics were measured by echocardiography, while fasting glucose, body mass index (BMI) and blood pressure were assessed with standard clinical techniques. Results: We found that p,p'-DDE levels were associated with increased fasting glucose, BMI, hypertension and LV mass in separate models adjusted for sex. Structural equation modeling revealed that the association between p,p'-DDE and LV mass was almost entirely mediated by BMI (70%), and also by hypertension (19%). Conclusion: The obesogenic effect of p,p'-DDE is a major determinant responsible for the association of p,p'-DDE with LV mass.
机译：背景和目的：农药代谢物p，p'-DDE与人和实验模型中左心室（LV）的质量以及左心室肥大的已知危险因素有关。我们假设p，p'-DDE与LV肥大危险因素（即血糖升高，肥胖和高血压）之间的关系介导了p，p'-DDE与LV体重的关系。方法：对70岁的乌普萨拉老年人脉管系统研究（PIVUS）的70岁受试者（n = 988）的血浆中的p，p'-DDE进行了测量。当这些受试者分别为70、75和80岁时，通过超声心动图测量LV特征，同时通过标准临床技术评估空腹血糖，体重指数（BMI）和血压。结果：我们发现，在针对性别进行调整的单独模型中，p，p'-DDE水平与空腹血糖，BMI，高血压和左室重量增加有关。结构方程模型表明，p，p'-DDE与左室重量之间的关联几乎完全由BMI（70％）和高血压（19％）介导。结论：p，p'-DDE的致肥胖作用是决定p，p'-DDE与左室重量相关的主要决定因素。

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  • 来源
    《Environmental research》 |2018年第1期|541-546|共6页
  • 作者

    M.A. La Merrill; P.M. Lind; S. Salihovic; B. van Bavel; L. Lind;

  • 作者单位

    Department of Environmental Toxicology, University of California, Davis, CA, USA;

    Department of Medical Sciences, Occupational and Environmental Medicine, Uppsala University, Uppsala, Sweden;

    Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden,MTM Research Centre, School of Science and Technology, Orebro University, Orebro, Sweden, and Norwegian Institute for Water Research, NTVA, Oslo, Norway;

    MTM Research Centre, School of Science and Technology, Orebro University, Orebro, Sweden, and Norwegian Institute for Water Research, NTVA, Oslo, Norway;

    Department of Medical Sciences, Cardiovascular Epidemiology, Uppsala University, Uppsala, Sweden;

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  • 正文语种 eng
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  • 关键词

    P,p'-DDE; Left ventricular hypertrophy; Obesity; Glucose; Hypertension;

    机译：P;p'-DDE;左心室肥大;肥胖;葡萄糖;高血压;

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