• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Environmental research >Association of blood polychlorinated biphenyls and cholesterol levels among Canadian Inuit
【24h】

Association of blood polychlorinated biphenyls and cholesterol levels among Canadian Inuit

机译：加拿大因纽特人中血液中多氯联苯与胆固醇水平的关联

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background: It has generally been thought that Inuit populations have low risk of cardiovascular disease due to high consumption of omega-3 fatty acids found in traditional marine-based diets. However, results of recent surveys showed that Inuit populations are experiencing increasing rates of cardiovascular disease and related risk factors. Objective: The purpose of this study was to investigate if blood polychlorinated biphenyls (PCBs) are associated with high cholesterol and related parameters in Canadian Inuit, known risk factors for cardiovascular disease. Methods: The Adult Inuit Health Survey (IHS, 2007-2008) included 2595 Inuit participants from three regions of the Canadian Arctic, of which 2191 could be classified as with or without high cholesterol. The high cholesterol outcome was defined by LDL-C > 3.36 mmol/L or taking medication(s) that reduce cholesterol, and was examined in adjusted logistic regression models with individual blood levels of PCB congeners, sum of dioxin-like PCBs (IDL-PCBs), or sum of non-dioxin-like PCBs (INDL-PCBs). Statistically significant covariates for high cholesterol were ranked in importance according to the proportion of the model log likelihood explained. Continuous clinical parameters of total cholesterol, triglycerides, LDL-C, and HDL-C were examined in multiple linear regression models with ZDL-PCBs or ZNDL-PCBs. Results: A total of 719 participants had high cholesterol (32.8%). PCBs were associated with increased risk of high cholesterol, and higher levels of serum triglycerides, total cholesterol, and LDL-C. No association was observed between PCBs and serum HDL-C. With respect to other statistically significant covariates for high cholesterol, the log likelihood ranking of PCBs generally fell between body mass index (BMI) and age. Conclusion: Further work is needed to corroborate the associations observed with PCBs and lipids in Canadian Inuit and to examine if they are causal in the direction anticipated.
机译：背景：人们普遍认为，因纽特人人群因食用传统海洋饮食中的Omega-3脂肪酸过多而患心血管疾病的风险较低。但是，最近的调查结果表明，因纽特人正在经历心血管疾病和相关危险因素的增加。目的：本研究的目的是调查血液多氯联苯（PCBs）是否与加拿大因纽特人（已知的心血管疾病危险因素）中的高胆固醇和相关参数有关。方法：成人因纽特人健康调查（IHS，2007-2008年）包括来自加拿大北极地区三个地区的2595名因纽特人参加者，其中2191人可分为高胆固醇或无高胆固醇。高胆固醇结局定义为LDL-C> 3.36 mmol / L或服用降低胆固醇的药物，并在调整后的Logistic回归模型中进行了检验，该模型包括多氯联苯同源物的单独血液水平，二恶英样多氯联苯（IDL- PCB）或非二恶英类PCB（INDL-PCB）的总和。根据解释的模型对数可能性的比例，对高胆固醇的统计学显着协变量进行重要性排名。使用ZDL-PCBs或ZNDL-PCBs在多个线性回归模型中检查了总胆固醇，甘油三酸酯，LDL-C和HDL-C的连续临床参数。结果：共有719位参与者具有高胆固醇（32.8％）。多氯联苯与高胆固醇风险增加，血清甘油三酸酯，总胆固醇和低密度脂蛋白胆固醇水平升高有关。多氯联苯和血清HDL-C之间未发现任何关联。关于高胆固醇的其他统计学上显着的协变量，PCBs的对数似然排名通常落在体重指数（BMI）和年龄之间。结论：需要做进一步的工作来证实在加拿大因纽特人身上观察到的与多氯联苯和脂质之间的联系，并检查它们是否在预期的方向上有因果关系。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号