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首页> 外文期刊>Environmental research >Prenatal exposure to mercury and longitudinally assessed fetal growth: Relation and effect modifiers
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Prenatal exposure to mercury and longitudinally assessed fetal growth: Relation and effect modifiers

机译：产前暴露于汞和经纵向评估的胎儿生长：关系和效应调节剂

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摘要

Background: Prenatal mercury exposure has been related to reductions in anthropometry at birth. Levels of mercury have been reported as being relatively elevated in the Spanish population. Objective: To investigate the relation between prenatal exposure to mercury and fetal growth. Methods: Study subjects were pregnant women and their newborns (n:1867) participating in a population-based birth cohort study set up in four Spanish regions from the INMA Project. Biparietal diameter (BPD), femur length (FL), abdominal circumference (AC), and estimated fetal weight (EFW) were measured by ultrasounds at 12, 20, and 34 weeks of gestation. Size at and growth between these points were assessed by standard deviation (SD) scores adjusted for constitutional characteristics. Total mercury (T-Hg) was determined in cord blood. Associations were investigated by linear regression models, adjusted by sociodemographic, environmental, nutritional - including four seafood groups - and lifestyle-related variables in each sub-cohort. Final estimates were obtained using meta-analysis. Effect modification by sex, seafood intake and polychlorinated biphenyl (PCB) congener 153 concentration was assessed. Results: Geometric mean of cord blood T-Hg was 8.2 μg/L. All the estimates of the association between prenatal Hg and growth from 0 to 12 weeks showed reductions in SD-scores, which were only statistically significant for BPD. A doubling of cord blood T-Hg was associated with a 0.58% reduction in size of BPD at week 12 (95% confidence interval -CI-: - 1.10, - 0.07). Size at week 34 showed estimates suggestive of a small reduction in EFW, i.e., a doubling of T-Hg levels was associated with a reduction of 0.38% (95% CI: - 0.91, 0.15). An interaction between PCB153 and T-Hg was found, with statistically significant negative associations of T-Hg with AC and EFW in late pregnancy among participants with PCB153 below the median. Conclusions: Exposure to mercury during pregnancy was associated with early reductions in BPD. Moreover, an antagonism with PCB 153 was observed with noteworthy reductions late in pregnancy in AC and EFW in the group with lower PCB153.
机译：背景：产前汞暴露与出生时人体测量学的减少有关。据报道，西班牙人口的汞含量相对较高。目的：探讨产前汞暴露与胎儿生长之间的关系。方法：研究对象是孕妇及其新生儿（n：1867），他们参加了一项基于人口的出生队列研究，该研究是在INMA项目的四个西班牙地区中建立的。在妊娠12、20和34周时通过超声测量双顶径（BPD），股骨长度（FL），腹围（AC）和估计的胎儿体重（EFW）。这些点的大小和在这些点之间的生长通过针对体质特征进行调整的标准差（SD）得分进行评估。测定脐带血中的总汞（T-Hg）。通过线性回归模型研究了相关性，并通过社会人口统计学，环境，营养（包括四个海鲜组）和每个子队列中与生活方式相关的变量进行了调整。使用荟萃分析获得最终估计。评估了性别，海鲜摄入量和多氯联苯（PCB）同类物153浓度对效果的影响。结果：脐血T-Hg的几何平均值为8.2μg/ L。所有有关产前汞与0至12周生长之间关系的估计都显示SD得分降低，这对BPD仅具有统计学意义。第12周时，脐血T-Hg加倍与BPD大小降低0.58％（95％置信区间-CI-：-1.10，-0.07）有关。第34周的大小显示出估计值，表明EFW略有减少，即T-Hg水平加倍与减少0.38％（95％CI：-0.91，0.15）有关。发现PCB153与T-Hg之间存在相互作用，在PCB153低于中位值的参与者中，妊娠晚期T-Hg与AC和EFW呈显着负相关。结论：怀孕期间接触汞与BPD的早期降低有关。此外，在PCB153较低的组中，观察到与PCB 153的拮抗作用，AC和EFW在妊娠后期明显减少。

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  • 来源
    《Environmental research》 |2018年第1期|97-106|共10页
  • 作者

    Ferran Ballester; Carmen Iniguez; Mario Murcia; Monica Guxens; Mikel Basterretxea; Marisa Rebagliato; Jesus Vioque; Aitana Lertxundi; Ana Fernandez-Somoano; Adonina Tardon; Jordi Sunyer; Sabrina Llop;

  • 作者单位

    Nursing School Universitat de Valencia, Valencia, Spain,FISABIO-Universitat Jaume I-Universitat de Valencia Joint Research Unit of Epidemiology and Environmental Health, Valencia, Spain,Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Spain;

    FISABIO-Universitat Jaume I-Universitat de Valencia Joint Research Unit of Epidemiology and Environmental Health, Valencia, Spain,Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Spain;

    Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Spain,FISABIO-Universitat Jaume I-Universitat de Valencia Joint Research Unit of Epidemiology and Environmental Health, Valencia, Spain;

    Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Spain,Universitat Pompeu Fabra, Barcelona, Spain,ISGlobal Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain,Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Centre-Sophia Children's Hospital Rotterdam, The Netherlands;

    Public Health Division of Gipuzkoa, San Sebastian, Spain,Health Research Institute (BIODONOSTIA), San Sebastian, Spain;

    FISABIO-Universitat Jaume I-Universitat de Valencia Joint Research Unit of Epidemiology and Environmental Health, Valencia, Spain,Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Spain,Medicine Department, Universitat Jaume I, Castello de la Plana, Spain;

    Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Spain,Universidad Miguel Hernandez, San Juan de Alicante, Spain;

    Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Spain,Universidad del Pais Vasco, Spain;

    Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Spain,IUOPA, Departamento de Medicina, Universidad de Ovieao, Spain;

    Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Spain;

    Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Spain,Universitat Pompeu Fabra, Barcelona, Spain,ISGlobal Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain;

    FISABIO-Universitat Jaume I-Universitat de Valencia Joint Research Unit of Epidemiology and Environmental Health, Valencia, Spain,Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Spain;

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  • 正文语种 eng
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  • 关键词

    Pregnancy; Mercury; Fetal growth; Seafood consumption; Polychlorinated biphenyl 153;

    机译：怀孕;汞;胎儿生长;海鲜消费;多氯联苯153;

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