Abstract Neurotransmitter changes in rat brain regions following glyphosate exposure
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Neurotransmitter changes in rat brain regions following glyphosate exposure

机译：草甘膦暴露后大鼠脑区域神经递质的变化

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AbstractThe effects of glyphosate oral exposure (35, 75, 150 and 800mg/kg bw, 6 days) on brain region monoamine levels of male Wistar rats were examined. Glyphosate-treated rats (35, 75, 150 and 800mg/kg bw, 6 days), had no visible injury,i.e.,no clinical signs of dysfunction were observed. After last dose of glyphosate, serotonin (5-HT), dopamine (DA) and norepinephrine (NE) and its metabolites levels were determined in the brain regions striatum, hippocampus, prefrontal, cortex, hypothalamus and midbrain, by HPLC. Glyphosate caused statistically significant changes in the 5-HT and its metabolite 5-hydroxy-3-indolacetic acid (5-HIAA), DA and its metabolites 3,4-hydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA), and NE and its metabolite 3-metoxy-4-hydroxyphenylethyleneglycol (MHPG) levels in a brain regional- and dose-related manner. Moreover, glyphosate, dose-dependent, evoked a statistically significant increase in 5-HT turnover in striatum and hypothalamus and in DA turnover in prefrontal cortex and hippocampus, and a statistically significant decrease in NE turnover in prefrontal cortex and hypothalamus. The present findings indicate that glyphosate significantly altered central nervous system (CNS) monoaminergic neurotransmitters in a brain regional- and dose-related manner, effects that may contribute to the overall spectrum of neurotoxicity caused by this herbicide.Highlights•Glyphosate oral exposure caused neurotoxicity in rats.•Brain regions were susceptible to changes in CNS monoamine levels.•Glyphosate reduced 5-HT, DA, NE levels in a brain regional- and dose-related manner.•Glyphosate altered the serotoninergic, dopaminergic and noradrenergic systems.
机译： 摘要 检查了草甘膦口服暴露（35、75、150和800mg / kg bw，6天）对雄性Wistar大鼠大脑区域单胺水平的影响。草甘膦处理的大鼠（35、75、150和800mg / kg bw，6天）没有可见的损伤，，即没有观察到功能障碍的临床迹象。在最后一次使用草甘膦后，通过HPLC测定了纹状体，海马，前额叶，皮层，下丘脑和中脑的大脑区域的5-羟色胺（5-HT），多巴胺（DA）和去甲肾上腺素（NE）及其代谢产物的水平。草甘膦在5-HT及其代谢物5-羟基-3-吲哚乙酸（5-HIAA），DA及其代谢产物3,4-羟基苯乙酸（DOPAC）和高香草酸（HVA）以及NE和其代谢物3-甲氧基-4-羟苯基乙二醇（MHPG）的水平与大脑区域和剂量相关。此外，草甘膦具有剂量依赖性，引起纹状体和下丘脑的5-HT转换以及前额叶皮层和海马的DA转换具有统计学意义的增加，前额叶皮层和下丘脑的NE转换具有统计学意义的降低。目前的发现表明，草甘膦以大脑区域和剂量相关的方式显着改变了中枢神经系统（CNS）单胺能神经递质，这种作用可能会导致这种除草剂引起的神经毒性的整个范围。 突出显示 • 草甘膦口服暴露对大鼠产生神经毒性。 • 脑区易受CNS单胺变化的影响级别。 • 草甘膦以与大脑区域和剂量相关的方式降低了5-HT，DA，NE水平。 • 草甘膦改变了5-羟色胺能，多巴胺能和诺拉能量系统。

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