Abstract Predictors and correlations of phthalate metabolite concentrations in urine and seminal plasma among reproductive-aged men
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Predictors and correlations of phthalate metabolite concentrations in urine and seminal plasma among reproductive-aged men

机译：育龄男性尿液和精浆中邻苯二甲酸盐代谢物浓度的预测因素和相关性

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摘要

AbstractBackgroundCertain phthalates are suspected to be endocrine disruptors that are adversely associated with male reproductive health. However, the predictors and correlations of phthalate metabolite concentrations in urine and seminal plasma among reproductive-aged men have not been thoroughly studied.ObjectiveTo investigate the predictors and correlations of phthalate metabolite concentrations in urine and seminal plasma among adult Chinese males.MethodWe measured mono-n-butyl phthalate (MBP), monobenzyl phthalate (MBzP), monomethyl phthalate (MMP), monoethyl phthalate (MEP), mono-n-octyl phthalate (MOP), mono(2-ethylhexyl) phthalate (MEHP), mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP) and mono(2-ethyl-5-oxohexyl) phthalate (MEOHP) concentrations in seminal plasma and repeated spot-urine samples from 687 men who visited a reproductive center. Mixed-effect models were used to examine the associations of sociodemographic, lifestyle and medical factors with urinary metabolite concentrations. Linear regression models were used to identify predictors of metabolite concentrations in seminal plasma and correlations between metabolite concentrations in spot urine samples and seminal plasma.ResultsMeasurements taken from spot urine samples poorly predicted same-day seminal plasma concentrations (allR2<0.10). Inverse associations were observed between education level and urinary MBP and MEOHP and between household income and urinary MMP; receiving intravenous infusion therapy was associated with increased urinary MBP, MEHHP and MEOHP, use of facial cleanser/cream was associated with increased MEP, and smoking was associated with increased MEHP. The predictors of metabolite concentrations in seminal plasma differed from those in urine, except for the association of intravenous infusion therapy with MBP. BMI was associated with increased seminal plasma MBP, MEHP and MEOHP, smoking was associated with increased MEP, and contact with plastics was associated with increased MEOHP.ConclusionsPhthalate metabolite concentrations in adult men varied in accordance with sociodemographic variables, lifestyle factors and intravenous therapy. Measures of metabolite levels in urine may not directly reflect the exposure status of the male reproductive system.Highlights•Phthalate metabolite levels in urine and seminal plasma were detected among 687 men.•Measures taken from urine samples poorly predicted same-day seminal plasma levels.•Metabolite levels varied according to sociodemographic and lifestyle factors.•Venous infusion was associated with higher levels of MBP and DEHP metabolites.
机译： 摘要 背景 某些邻苯二甲酸酯被怀疑是内分泌干扰物与男性生殖健康有不利关系。但是，尚未全面研究育龄男性尿液和精浆中邻苯二甲酸酯代谢物浓度的预测因素和相关性。 目标 调查成年男性尿液和精浆中邻苯二甲酸酯代谢物浓度的预测因素及其相关性。 方法 我们测量了邻苯二甲酸单正丁酯（MBP），邻苯二甲酸单苄酯（MBzP），邻苯二甲酸单甲酯（MMP），邻苯二甲酸单乙酯（MEP），邻苯二甲酸单 n -邻苯二甲酸辛酯（MOP） ，邻苯二甲酸单（2-乙基己基）（MEHP），邻苯二甲酸单（2-乙基-5-羟基己基）（MEHHP）和邻苯二甲酸单（2-乙基-5-氧己基）精子血浆中的te（MEOHP）浓度以及来自生殖中心的687名男性的重复尿样样本。混合效应模型用于检查社会人口统计学，生活方式和医学因素与尿液代谢产物浓度之间的关系。使用线性回归模型确定精浆中代谢物浓度的预测因子以及尿液现货样品和精浆中代谢物浓度之间的相关性。 结果 从尿液样本中获取的测量值不能很好地预测当天的精浆浓度（all R 2 <0.10）。观察到教育水平与尿液MBP和MEOHP之间以及家庭收入与尿液MMP之间呈负相关。接受静脉输液治疗与尿液MBP，MEHHP和MEOHP升高有关，使用洗面奶/乳霜与MEP增加有关，而吸烟与MEHP增加有关。除了静脉输注疗法与MBP的关联外，精浆中代谢物浓度的预测因子与尿中的预测因子不同。 BMI与精浆MBP，MEHP和MEOHP升高有关，吸烟与MEP升高有关，与塑料接触与MEOHP升高有关。 结论 突出显示 • • 从尿液样本中获取的测量值无法很好地预测当天的精浆水平。 • 代谢物水平根据社会人口统计学和生活方式而异因素。 • 静脉输注与更高水平的MBP和DEHP代谢产物有关。

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  • 来源
    《Environmental research》 |2018年第2期|336-344|共9页
  • 作者

    Yi-Xin Wang; Chong Liu; Ying-Jun Chen; Heng-Gui Chen; Pan Yang; Peng Wang; Li-Li Huang; Song-Hua Ai; Peng Duan; An Pan; Qiang Zeng; Wen-Qing Lu;

  • 作者单位

    Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology,Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental health (incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology;

    Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology,Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental health (incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology;

    Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology,Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental health (incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology;

    Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology;

    Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology,Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental health (incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology;

    Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology;

    Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology,Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental health (incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology;

    Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology,Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental health (incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology;

    Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology,Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental health (incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology;

    Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology;

    Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology,Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental health (incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology;

    Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology,Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental health (incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology;

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  • 正文语种 eng
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  • 关键词

    Correlation; Males; Phthalates; Predictor; Seminal plasma; Urine;

    机译：相关性男性邻苯二甲酸盐预测因子血浆;尿液;

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